[关键词]
[摘要]
青光眼性视神经病变(GON)是青光眼治疗难点所在。近年来，关于GON的发病机制提出了多种学说，但其中任何一种均无法解释所有类型青光眼造成的视神经病变原理，使得该病在临床治疗中顾此失彼，且不利于早期干预。最新研究发现，存在于视网膜中的瞬时受体电位通道香草酸亚家族4(TRPV4)在GON多种发病机制中均占有重要地位。本文将对TRPV4及其在GON发生发展过程中所发挥的作用作一综述，以期为GON的多种机制学说寻找一共同“连接点”，这将有助于对该病的进一步认识和临床治疗。
[Key word]
[Abstract]
Glaucomatous optic neuropathy(GON)is the difficulty of glaucoma treatment. In recent years, a variety of theories have been put forward about the pathogenesis of GON, but none of them can explain the principle of optic neuropathy caused by all types of glaucoma, which makes the disease difficult to treat in clinical treatment and is not conducive to early intervention. The latest research found that the transient receptor potential channel vanillic acid subfamily 4(TRPV4)in the retina plays an important role in various pathogenesis of GON. This article will review TRPV4 and its role in the occurrence and development of GON in order to find a common “connection point” for the multiple mechanism theories of GON, which will contribute to further understanding and clinical treatment of the disease.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82274588,81904260); 中医药防治五官科疾病湖南省重点实验室建设项目(No.2017TP1018); 湖南省教育厅科学研究青年项目(No.22B0398); 湖南省研究生科研创新项目(No.CX20230790)
