除风益损汤加减方对翼状胬肉术后眼表炎症的影响

Effect of modified Chufeng Yisun Decoction on ocular surface inflammation after pterygium surgery

摘要:

目的：探讨除风益损汤加减方对翼状胬肉术后眼表炎症的影响。

方法：将接受翼状胬肉手术治疗的60例60眼原发性翼状胬肉患者随机分为对照组(30例30眼，术后应用普拉洛芬滴眼液、妥布霉素地塞米松滴眼液及小牛血去蛋白提取物眼用凝胶滴眼治疗)和观察组(30例30眼，在对照组治疗方案的基础上联合口服中药除风益损汤加减方治疗)。观察两组患者的眼部疼痛评分、眼部炎性体征、泪液中IL-6水平及泪液蕨样变试验(TFT)的变化。

结果：两组患者术后2d，1wk视觉模拟评分量表(VAS)评分均低于术后1d(均P<0.01)，术后2d，1wk观察组VAS评分优于对照组(P<0.01)。两组术后1wk眼部炎性体征总分(OSI)、TFT均优于术后1d(均P<0.01)，观察组术后1wk OSI、TFT优于对照组(均P<0.01)。两组术后1wk泪液IL-6浓度均低于术后1d(均P<0.01)，观察组术后1wk泪液IL-6浓度低于对照组(P<0.05)。

结论：除风益损汤加减方联合常规西医治疗具有更好地控制翼状胬肉术后眼表炎症的作用。

Abstract:

AIM: To investigate the effect of modified Chufeng Yisun Decoction on ocular surface inflammation after pterygium surgery.

METHODS: A total of 60 patients(60 eyes)with primary pterygium who underwent pterygium surgery were randomly divided into control group and study group, with 30 cases(30 eyes)in each group. In the control group, patients were treated with pranoprofen eye drops, tobramycin dexamethasone eye drops, and deproteinized calf blood extract eye gel after the surgery. In the study group, patients were treated by oral modified Chufeng Yisun Decoction in addition to the treatments in the control group. The changes of ocular irritation symptoms, ocular inflammatory signs, tear interleukin 6(IL-6)levels, and tear ferning test(TFT)of patients in the two groups were assessed.

RESULTS: The visual analogue scale(VAS)in patients of both groups was significantly lower at 2d and 1wk after the surgery than that at 1d after the surgery(all P<0.01), and the VAS of the study group was significantly better than that of the control group at 2d and 1wk after surgery(P<0.01). The ocular signs integrals(OSI)and TFT results of both groups at 1wk were significantly lower than those at 1d after the surgery(all P<0.01), and the OSI and TFT were also lower in the study group than in the control group at 1wk after the surgery(all P<0.01). In addition, the concentration of tear IL-6 in both groups was significantly lower at 1wk after the surgery than 1d after the surgery(all P<0.01), and it was also significantly lower in the study group than in the control group at 1wk after the surgery(P<0.05).

CONCLUSION: The combination of Chufeng Yisun Decoction and conventional treatment of western has a better effect on controlling ocular surface inflammation after pterygium surgery.