微流控芯片在年龄相关性黄斑变性中的研究进展

Research progress of microfluidic chips in age-related macular degeneration

摘要:

年龄相关性黄斑变性(ARMD)是导致60岁以上人群视力严重受损与失明的重要原因。随着全球人口老龄化，该病的发病率也在逐年上升。然而，目前ARMD的发病机制和治疗方案仍需深入探究。作为一门新兴的前沿科学技术，微流控芯片技术可以构建模拟人体组织和器官功能的综合微系统，具有样品消耗少、分析时间短等优势。近年来，大量研究证实微流控芯片能为ARMD的基础及临床研究带来全新的技术解决方案。本文对微流控芯片在ARMD机制研究、药物评价和临床转化等方面的应用进展予以讨论和回顾，为进一步研究ARMD的诊疗提供理论参考。

Abstract:

Age-related macular degeneration(ARMD)is the primary cause of severe visual impairment and blindness in people over 60 years old. With the aging of the global population, the incidence of the disease is also rising year by year. However, the pathogenesis and treatment strategy of ARMD need to be further explored. As a cutting-edge science and technology, microfluidic chips can build a comprehensive microsystem that simulates the condition and function of human tissues and organs, which has the advantages of less sample consumption and short analysis time. In recent years, many studies have confirmed that microfluidic chips can bring brand new technology solutions to the basic and clinical research of ARMD. This article will discuss and review the application progress of microfluidic chips in the areas of ARMD mechanism research, drug evaluation and clinical translation, providing a theoretical reference for further research on the diagnosis and treatment of ARMD.