目的：研究睑板腺功能障碍(MGD)与睡眠质量之间的相关性。

方法：回顾性病例对照研究。选取2021-01/2022-10我院收治的MGD患者150例，根据匹兹堡睡眠质量指数(PSQI)量表评分分为睡眠障碍组(75例，PSQI>10分)和对照组(75例，PSQI≤10分)，均进行眼表疾病指数量表(OSDI)评分和睑板腺相关检查(睑缘形态、睑板腺分泌能力、睑板腺分泌物性质评分)、角膜荧光素染色(FL)评分、基础泪液分泌试验(SⅠt)，检测泪膜破裂时间(BUT)，评估睡眠指标(睡眠质量、睡眠潜伏期、主观睡眠质量、睡眠时间)。

结果：两组患者OSDI评分、FL评分、SⅠt、BUT、睑缘形态评分、睑板腺分泌能力评分、睑板腺分泌物性质评分均有差异(P<0.05)。睡眠障碍组患者PSQI评分、睡眠潜伏期评分、主观睡眠质量评分、睡眠时间评分与OSDI评分、FL评分、睑板腺分泌能力评分和睑板腺分泌物性质评分均呈显著正相关性(P<0.05)； PSQI评分、主观睡眠质量评分、睡眠时间评分与睑缘形态评分均呈显著正相关性(P<0.05)； PSQI评分、睡眠潜伏期评分、主观睡眠质量评分与BUT、SⅠt均呈显著负相关性(P<0.05)； 睡眠时间评分与BUT呈显著负相关性(P<0.05)； 睡眠潜伏期评分与睑缘形态评分无明显相关性(P>0.05)； 睡眠时间评分与SⅠt无显著相关性(P>0.05)。

结论：MGD患者眼表情况与多项睡眠质量指标均具有相关性，睡眠质量下降可能增加MGD的患病风险。

METHODS: Retrospective case-control study. A total of 150 MGD patients treated in our hospital from January 2021 to October 2022 were selected and divided into sleep disorder group(75 cases, PSQI>10 points)and control group(75 cases, PSQI≤10 points)according to the Pittsburgh sleep quality index(PSQI). Both groups were scored using the ocular surface disease index(OSDI), underwent meibomian gland-related examinations(eyelid margin morphology, meibomian gland secretion ability, meibomian gland secretion quality score), corneal fluorescein staining(FL)score, Schirmer Ⅰ test(SⅠt), tear film break-up time(BUT)was measured, and sleep indicators(sleep quality, sleep latency, subjective sleep quality, sleep time)were evaluated.

RESULTS: There were significant differences in OSDI score, FL score, SⅠt, BUT, eyelid margin morphology score, meibomian gland secretion ability score, and meibomian gland secretion quality score between the two groups(P<0.05). In the sleep disorder group, PSQI score, sleep latency score, subjective sleep quality score, and sleep time score were significantly positively correlated with OSDI score, FL score, meibomian gland secretion ability score, and meibomian gland secretion quality score(P<0.05); PSQI score, subjective sleep quality score, and sleep time score were significantly positively correlated with eyelid margin morphology score(P<0.05); PSQI score, sleep latency score, and subjective sleep quality score were significantly negatively correlated with BUT and SⅠt(P<0.05); sleep time score was significantly negatively correlated with BUT(P<0.05); sleep latency score was not significantly correlated with eyelid margin morphology score(P>0.05); sleep time score was not significantly correlated with SⅠt(P>0.05).

CONCLUSION:The ocular surface condition of MGD patients is correlated with multiple sleep quality indicators, and a decline in sleep quality may increase the risk of MGD.