地夸磷索钠联合清润养目口服液治疗白内障术后干眼

Diquafossol sodium combined with Qingrun Yangmu oral liquid for the treatment of dry eye after cataract operation

摘要:

目的：探讨地夸磷索钠滴眼液联合清润养目口服液治疗白内障超声乳化摘除术联合人工晶状体植入术后干眼的临床疗效。

方法：选取2020-09/2021-01就诊于我院眼科的白内障术后干眼患者57例65眼作为研究对象，采用随机数字表法分为对照组(28例32眼，使用3%地夸磷索钠滴眼液治疗)和观察组(29例33眼，使用3%地夸磷索钠滴眼液联合清润养目口服液治疗)。比较两组患者术前1d，术后1wk(治疗前)，1mo(治疗后)眼表疾病指数(OSDI)量表评分、非侵入性泪膜破裂时间(NIBUT)、泪液分泌试验(SⅠt)、角膜荧光素钠染色(CFS)评分、中医症状评分等指标。

结果：治疗后，观察组和对照组总有效率分别为88%、75%，两组患者OSDI评分、NIBUT、SⅠt均较治疗前明显改善(P<0.05)，观察组治疗后NIBUT、SⅠt、CFS评分、中医症状评分均优于对照组(P<0.05)。治疗期间，两组患者均无不良反应发生。

结论：地夸磷索钠滴眼液联合清润养目口服液可改善白内障术后干眼的主观症状及客观临床指标，为白内障围手术期干眼的眼表管理提供了新的治疗方案。

Abstract:

AIM: To investigate the clinical efficacy of diquafosol sodium(DQS)eye drops combined with Qingrun Yangmu oral liquid in the treatment of dry eye after phacoemulsification and intraocular lens implantation.

METHODS:A total of 57 patients(65 eyes)with dry eye after cataract surgery, who were admitted to the ophthalmology department of our hospital from September 2020 to January 2021, were selected as the research objects. They were divided into a control group(28 cases, 32 eyes, treated with 3% DQS eye drops)and an observation group(29 cases, 33 eyes, treated with 3% DQS eye drops combined with the Qingrun Yangmu oral liquid)based on a random number table method. Indicators, such as ocular surface disease index(OSDI), non-invasive tear film break-up time(NIBUT), Schirmer I test(SIt), corneal fluorescein sodium staining(CFS), and TCM symptom score, were compared and analyzed between the two groups 1d before, 1wk after(before treatment), and 1mo after(after treatment)surgery.

RESULTS:The total effective rates of the observation group and the control group after treatment were 88% and 75%, respectively. The OSDI, NIBUT and SIt of the two groups after treatment showed significant improvement compared to those before treatment(P<0.05). The NIBUT, SIt, CFS, and TCM symptom scores of the observation group after treatment were better than those of the control group(P<0.05). No adverse reactions were observed in both groups.

CONCLUSION:Combined use of DQS eye drops and the Qingrun Yangmu oral liquid can improve symptoms and clinical indicators of dry eye after cataract surgery, providing a new treatment method for ocular surface management of dry eye during the perioperative period of cataract surgery.