低能量红光对近视儿童脉络膜厚度和等效球镜度及眼轴长度的影响

Effects of low-energy red light on choroidal thickness and spherical equivalent and axial length in myopic children

摘要:

目的：系统评价低能量红光对于近视儿童脉络膜厚度(ChT)和等效球镜度(SE)及眼轴长度(AL)的影响。

方法：通过检索Pubmed、Embase、Cochrane Library、Web of Science、中国知网、万方、维普网及中国生物医学文献数据库共8个数据库，从建库至2023-01期间所有关于低能量红光干预近视发展的随机对照试验，红光干预作为试验组，仅配戴单焦眼镜作为对照组。按照Cochrane手册要求进行文献质量及偏倚风险评价。Meta分析由Revman5.4软件完成。

结果：共计纳入8篇有关低能量红光干预近视发展的随机对照试验研究。用于分析ChT变化的样本量为红光组407眼，对照组425眼； 用于分析SE变化差值的样本量为红光组490眼，对照组518眼； 纳入AL分析的样本量为红光组518眼，对照组539眼。红光组与对照组ChT、SE、AL比较均有差异(ChT：WMD=37.81，95%CI：21.55～54.07，P<0.001； SE：WMD=0.58，95%CI：0.46～0.71，P<0.001； AL：WMD=-0.31，95%CI：-0.39～-0.24，P<0.001)。

结论：特定的红光有助于促进ChT而抑制SE及AL增加，但其远期效果及副作用尚不清楚，上述结论还需要更多大样本的随机对照研究进一步明确。

Abstract:

AIM: To systematically evaluate the effects of low-energy red light on choroidal thickness(ChT), spherical equivalent(SE), and axial length(AL)in myopic children.

METHODS: A total of 8 databases, including Pubmed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Database, VIP Database and China Biomedical Literature Database, were electronically retrieved to collect the clinical randomized controlled trial(RCT)of low-energy red light in myopia, with red light intervention as an experimental group and glasses as a control group. The retrieval time limit is from the establishment of the database to January 2023. According to the recommendation of the Cochrane Handbook, literature quality and risk of bias were evaluated. Revman5.4 software was used for Meta-analysis.

RESULTS: Totally 8 RCT about red-light treatment with myopia were included. The sample size for ChT analysis contained 407 eyes in the red-light group and 425 eyes in the control group; SE analysis included 490 eyes in the red-light group and 518 eyes in the control group; sample size for AL analysis were 518 eyes in the red-light group and 539 eyes in the control group. The differences in ChT, SE and AL between the groups were statistically significant(ChT: WMD=37.81, 95%CI: 21.55～54.07, P<0.001; SE: WMD=0.58, 95%CI: 0.46～0.71, P<0.001; AL: WMD=-0.31, 95%CI: -0.39～-0.24, P<0.001).

CONCLUSION: Specific red light can promote the increase of ChT while inhibit SE and AL. However, its long-term efficacy and side effects remain unclear. The above conclusions need to be further clarified by more RCT with large samples.