IL-6在眼部炎性疾病中的作用
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国家自然科学基金青年科学基金项目(No.82000911,82201219); 苏州市科技发展计划项目(No.SYSD2020072)


Role of interleukin-6 in ocular inflammatory diseases
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Youth Science Foundation Project of National Natural Science Foundation of China(No.82000911, 82201219); Suzhou Science and Technology Development Plan Project(No.SYSD2020072)

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    摘要:

    白细胞介素-6(interleukin-6, IL-6)是由单核细胞、巨噬细胞、T淋巴细胞及其他细胞类型产生的多效性细胞因子,在感染和炎症过程中显著上调,是宿主抵御环境压力(如损伤和感染)的核心细胞因子。异常及持续的IL-6的产生与各种自身免疫及炎症性疾病的发展密切相关。越来越多的研究表明,IL-6在眼结膜、角膜、葡萄膜、视网膜等部位的炎症和血管生成中发挥重要作用。IL-6的阻断可以改善眼部慢性、难治性炎症。本文就IL-6在眼部炎症性疾病中的作用及机制进行综述,以期深入、系统地了解IL-6在眼部炎症性疾病中的作用。

    Abstract:

    Interleukin-6(IL-6)is a pleiotropic cytokine produced by monocytes, macrophages, T lymphocytes and other cell types. It is significantly up-regulated in the process of infection and inflammation, and is the core cytokine of the host's defense against environmental stresses(such as injury and infection). Abnormal and persistent IL-6 production is closely associated with the development of various autoimmune and inflammatory diseases. A growing number of studies have shown that IL-6 plays a critical role in ocular inflammation and angiogenesis in the conjunctiva, cornea, uvea and retina. Blockade of IL-6 ameliorates chronic and refractory intraocular inflammation. This article aims to review the role as well as the mechanism of IL-6 in ocular inflammatory diseases, attempting to have a deep and systematic understanding of the role of IL-6 in ocular inflammatory diseases.

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涂园园,朱曼辉. IL-6在眼部炎性疾病中的作用.国际眼科杂志, 2023,23(5):774-777.

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  • 收稿日期:2022-07-25
  • 最后修改日期:2023-03-30
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  • 在线发布日期: 2023-04-27
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