二甲双胍在年龄相关性眼病中应用的研究进展

Research progress on the application of metformin in age-related eye diseases

摘要:

年龄相关性眼病是眼组织退行性病变所引发的一系列眼科疾病，年龄相关性黄斑变性(ARMD)、年龄相关性白内障(ARC)、糖尿病视网膜病变(DR)和青光眼是四种最为常见的年龄相关性眼病。随着全球社会人口老龄化的加剧，这些眼病的发病率也逐年攀升。二甲双胍是目前临床上最常用的降血糖药之一，经过60多年的临床实践，已成为治疗2型糖尿病的首选用药。近年来，二甲双胍在防治肿瘤、各系统疾病及年龄相关性疾病中展现出巨大潜力，其中涉及的抗氧化应激、抗炎、诱导自噬等作用机制也与年龄相关性眼病的病理变化密切相关。本文旨在对二甲双胍在年龄相关性眼病中的研究现状及潜在应用价值进行综述。

Abstract:

Age-related eye diseases are a series of ophthalmic diseases caused by degenerative disease of ocular tissues, and age-related macular degeneration(ARMD), age-related cataract(ARC), diabetic retinopathy(DR)and glaucoma are the four most common age-related eye diseases. With the increasing aging of the global social population, the incidence of these eye diseases is also increasing year by year. Metformin is currently one of the most commonly used hypoglycemic agents in clinical practice. It has become the drug of choice for treating type 2 diabetes after more than 60 years of clinical practice. In recent years, metformin has shown great potential in the prevention and treatment of tumors, systemic diseases and age-related diseases, and the mechanisms of action involved in anti-oxidative stress, anti-inflammation, and induction of autophagy are also closely related to the pathological changes of age-related eye diseases. The paper aims to review the current research status and potential application value of metformin in age-related eye diseases.