色素上皮衍生因子在眼部疾病中的研究进展

Research progress of pigment epithelial-derived factor in ocular diseases

摘要:

色素上皮衍生因子(PEDF)是分子量为50kDa的一种分泌型糖蛋白，最初发现由色素上皮细胞分泌，随后发现其广泛分布于全身多种器官组织中并发挥多种生物学作用。近年来，大量研究已经证实PEDF在眼部组织中通过与多种受体结合启动广泛的细胞反应，具有调节血管生成、抗炎、抗氧化应激和营养神经的作用。新近的研究发现，应用外源性PEDF在干眼和角膜损伤的修复方面具有较好治疗效果。除此外，通过编码PEDF基因的治疗方法在年龄相关性黄斑变性及糖尿病视网膜病变的治疗中也展现出良好前景。本综述主要对近年来PEDF在干眼、角膜损伤、年龄相关性黄斑变性和糖尿病视网膜病变等疾病中的潜在治疗作用及局限性做简要概述，为进一步研究PEDF在诊治眼部疾病方面提供帮助。

Abstract:

As a secreted glycoprotein with a molecular weight of 50kDa, pigment epithelial-derived factor(PEDF)was originally found to be secreted by pigment epithelial cells; afterwards, it was found to be widely distributed in various organs and tissues throughout the body and played multiple biological roles. In recent years, a large number of studies have confirmed that PEDF can initiate a wide range of cellular responses in eye tissues by binding with a variety of receptors, which has the functions of regulating angiogenesis, anti-inflammatory, antioxidant stress and neurotrophic. Recent studies have found that the application of exogenous PEDF has a preferable therapeutic effect on the repair of dry eye and corneal injury. In addition, the PEDF gene encoding therapy has shown promising in the treatment of age-related macular degeneration and diabetic retinopathy. This review mainly summarizes the potential therapeutic effects and limitations of pigment epithelium-derived factors in dry eye, corneal injury, age-related macular degeneration, diabetic retinopathy and other diseases in recent years, which provides help for further research on the diagnosis and treatment of ocular diseases with PEDF.