眼睑痉挛型Meige综合征的治疗进展

Advances in the treatment of Meige's syndrome with blepharospasm

摘要:

Meige综合征是一种节段性的颅颈部肌张力障碍性的锥体外系疾病，属于成人多动症的一种。发病原因不明，常见于中老年女性，多与抑郁、外伤、药物、手术等危险因素相关，眼睑痉挛是Meige综合征最早也是最常见的临床症状，尽管有自发缓解的可能，但亦有致盲风险，临床上多因对此病认识不足而延误治疗影响预后，随着其发病率的增长，尤其以眼睑痉挛就诊于眼科的人数增长，全面认识Meige综合征有利于提高眼科医师诊治本病的能力以及指导临床合理用药。本文就眼睑痉挛型Meige综合征的治疗进展予以综述，总结了药物、手术和中医疗法的利弊，以期提高眼科医师对此类疾病的诊治水平。

Abstract:

Meige's syndrome is a segmental craniocervical dystonia extrapyramidal disorder, which belongs to a type of adult attention deficit and hyperactivity disorder(ADHD). The cause is unknown and is commonly seen in middle-aged and elder women, and is often associated with depression, trauma, drugs, surgery and other risk factors. Blepharospasm is the earliest and most common clinical symptom of Meige's syndrome, although there is a possibility of spontaneous remission, the risk of blindness still exists. Clinically, treatment is often delayed and the prognosis is influenced due to insufficient understanding of Meige's syndrome. As the incidence of Meige syndrome increases, particularly blepharospasm in ophthalmology, a comprehensive understanding of Meige's syndrome is needed to improve the ability of ophthalmologists to treat the condition and to guide the appropriate use of clinical medication. In this paper, we review advances in the treatment of Meige's syndrome with blepharospasm and summarize the pros and cons of pharmacotherapy, surgery and traditional Chinese medicine, with a view to improving the diagnosis and treatment of this disease by ophthalmologists.