[关键词]
[摘要]
随着跨入高科技发展时代，人们进行屏幕作业的时间越来越长，绝大多数屏幕都含有大量蓝光，作为可见光的重要组成部分之一，蓝光具有较高的能量，眼睛长期暴露于蓝光下可能会导致近视、白内障、干眼、青光眼和角膜炎等眼部疾病。蓝光危害及如何防蓝光成为社会中的热门话题，其作用机制主要包括增加脂褐素光敏性、破坏线粒体、溶酶体、晶状体和泪膜等。根据蓝光损伤的机制，可以采用物理防护措施和使用抗氧化剂、自由基清除剂、抗炎药物和基因治疗来保护眼组织。本文主要总结了蓝光对眼部的危害作用机制及相应的防治措施。
[Key word]
[Abstract]
With the development of high technology, people spend more and more time on screens. Most screens contain a lot of blue light. As one of the important components of visible light, blue light has high energy. It may lead to many ocular diseases, such as myopia, cataract, dry eye, glaucoma and keratitis when eyes exposure to blue light for a long time. At present, the harm of blue light and how to prevent blue light have become a hot topic. Its mechanism mainly includes increasing the photosensitivity of lipofuscin, destroying the mitochondria, lysosome, lens and tear film. According to the mechanism of blue light damage, physical protective measures can be adopted. And the antioxidant, free radical scavengers, anti-inflammatory drugs and gene therapy can be used to protect eye tissue. This paper mainly summarizes the harmful mechanism of blue light to eye and the corresponding prevention and treatment measures.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82160195); 中央引导地方科技发展专项资金(No.20211ZDG02003); 江西省重点研发计划项目(No.20181BBG70004,20203BBG73059)
