iTrace和Pentacam及LOCSⅢ参数在晶状体混浊程度评估中的相关性

Correlations among parameters of iTrace, Pentacam and lens opacities classification system Ⅲ in lens opacity assessment

摘要:

目的：分析iTrace视功能分析仪和Pentacam三维眼前节分析系统及晶状体混浊分级系统Ⅲ(LOCSⅢ)在年龄相关性白内障(ARC)患者晶状体混浊评估中的相关性。

方法：前瞻性横断面研究。纳入2021-05/08本院眼科的ARC患者104例104眼。裂隙灯行LOCSⅢ分级； iTrace获取晶状体混浊地形图分级(OMG)和晶状体功能失调指数(DLI)； Pentacam获取核分级(PNS)和Scheimpflug图像，ImageJ测量Scheimpflug图像各区域的累积光密度(IntDen)。SPSS 26.0分析参数正态性和相关性。

结果：各参数除3mm范围IntDen和6mm范围后囊区IntDen外均正态分布。PNS与NC、NO均正相关(r=0.521、0.440，均P<0.01)。3mm范围IntDen与NC、NO均正相关(r_s=0.459、0.450，均P<0.01)。3mm范围核区IntDen与NC、NO均正相关(r=0.539、0.543，均P<0.01)。3mm范围后囊区IntDen与NC、NO均负相关(r=-0.315、-0.321，均P<0.01)。6mm范围IntDen与NC、NO均正相关(r=0.321、0.288，均P<0.01)。3mm范围DLI与NC、NO、PSC均负相关(r=-0.257、-0.234、-0.282，均P<0.01)。6mm DLI与NC、NO、PSC均负相关(r=-0.247、-0.304、-0.227，均P<0.05)。3mm范围OMG与CC、PSC均正相关(r=0.268、0.333，均P<0.01)。6mm范围OMG与CC、PSC均正相关(r=0.275、0.245，均P<0.05)。3mm范围DLI与PNS、3mm范围核区IntDen均负相关(r=-0.217、-0.197，均P<0.05)。

结论：三种晶状体混浊评价系统各有优势，将各参数结合可更客观地评价晶状体各区混浊，为临床提供参考。

Abstract:

AIM: To analyze the correlations among parameters from iTrace visual function analyzer, Pentacam 3D anterior segment analysis system and lens opacities classification system(LOCS)Ⅲ in the assessment of lens opacity of age-related cataract(ARC)patients.

METHODS: A prospective cross-sectional study. A total of 104 ARC patients(104 eyes)in the department of ophthalmology of our hospital from May to August, 2021 were included. The cataracts of patients were graded based on LOCSⅢ using a slit-lamp. Opacity map grade(OMG)and dysfunctional lens index(DLI)were obtained by iTrace. Pentacam nucleus staging(PNS)and Scheimpflug images of lenses were acquired by Pentacam. The regional integrated density(IntDen)of Scheimpflug images was obtained by ImageJ. The normality and correlations of parameters were analyzed by SPSS 26.0.

RESULTS: All the parameters were normally distributed except 3mm IntDen and IntDen of 6mm posterior subcapsular region. PNS positively correlated with nuclear color(NC)and nuclear opalescence(NO)(r=0.521, 0.440, all P<0.01). The 3mm IntDen positively correlated with NC and NO(r_s=0.459, 0.450, all P<0.01). IntDen of 3mm nucleus region positively correlated with NC and NO(r=0.539, 0.543, all P<0.01). IntDen of 3mm posterior subcapsular region was negatively correlated with NC and NO(r=-0.315, -0.321, all P<0.01). 6mm IntDen positively correlated with NC and NO(r=0.321, 0.288, all P<0.01). 3mm DLI negatively correlated with NC, NO, and posterior subcapsular cataract(PSC)(r=-0.257, -0.234, -0.282, all P<0.01). 6mm DLI negatively correlated with NC, NO, PSC(r=-0.247, -0.304, -0.227, all P<0.05). 3mm OMG positively correlated with CC and PSC(r=0.268, 0.333, all P<0.01), and 6mm OMG positively correlated with CC and PSC(r=0.275, 0.245, all P<0.05). 3mm DLI negatively correlated with PNS and IntDen of 3mm nucleus region(r=-0.217, -0.197, all P<0.05).

CONCLUSION:Each lens opacity assessment system had its own advantages. Taking all parameters into comprehensive consideration is conducive to objectively eraluate the opacity degree of each area of the lens and provide references for clinical work.