目的：使用中文版间歇性外斜视生活质量量表(CIXTQ)评估间歇性外斜视(IXT)对患者及其家属生活质量的影响。

方法：搜集2020-06/2021-06于南京市儿童医院眼科住院的IXT患者及同等数量年龄匹配的正常儿童的CIXTQ得分资料。即儿童量表(CIXTQ，用于儿童评估自己的生活质量)得分，家长代理量表(pp-CIXTQ，用于家长评估儿童的生活质量)得分和家长量表(p-CIXTQ，用于家长评估自身的生活质量)得分。分析：(1)IXT儿童与正常儿童CIXTQ，pp-CIXTQ及p-CIXTQ得分的差异；(2)IXT儿童CIXTQ与pp-CIXTQ评分之间的关系；(3)IXT患儿生活质量影响因素。

结果：共纳入156例IXT儿童和156名年龄匹配的正常儿童。IXT组儿童的CIXTQ得分低于对照组(t=-12.915，P<0.001)。IXT组CIXTQ与pp-CIXTQ得分比较无差异(t=-0.718，P=0.473)。单条目分析发现，IXT组儿童更关注别人对他们的看法和自己的视力，而父母则更关心孩子是否需要手术，斜视是否会对孩子眼睛造成永久性损害以及斜视是否影响他们的社交生活。

结论：CIXTQ能较好地区分IXT儿童与正常儿童的生活质量，能准确预测IXT对患儿的影响，有助于制定个性化临床治疗方案。

METHODS: The scores of CIXTQ were collected from IXT children and the same number of age-matched control children in department of ophthalmology, Nanjing Children's Hospital from June 2020 to June 2021. They were the Chinese version of intermittent exotropia questionnaires scores(CIXTQ, for children to assess their health related quality of life), the parental proxy CIXTQ(pp-CIXTQ, for parents to assess children's life quality)scores and the parent CIXTQ(p-CIXTQ, for parents to assess their life quality)scores. To explore: 1)The differences in the CIXTQ, pp-CIXTQ and p-CIXTQ scores between IXT children and the normal children; 2)The relationship between the CIXTQ and pp-CIXTQ scores in IXT children; 3)The factors affecting the quality of life in children with IXT.

RESULTS: A total of 156 patients with IXT and 156 age-matched normal children were included. CIXTQ scores in the children with IXT group was lower than that in the control group(t=-12.915, P<0.001). In IXT group, there was no difference observed in CIXTQ or pp-CIXTQ scores(t=-0.718, P=0.473). As suggested by item-level analysis, children in the IXT group were more concerned about how others think of them and their vision, whereas parents were more concerned about whether the child needs surgery, and whether the permanent damage of strabism caused to the eyes of their children and whether strabismus affects their social life.

CONCLUSION: The CIXTQ performed better in distinguishing the children with IXT and those with normal condition, and it can accurately predict the impact of IXT on children, and benefit to make personalized treatment regimens.