[关键词]
[摘要]
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是一种在夜间睡眠过程中上呼吸道短暂的、反复发作的、部分或完全阻塞的一组疾病，其可以影响机体血流动力学、内分泌和自主神经调节，进而导致机体氧饱和度降低、慢性缺氧和高碳酸血症。OSAHS除了是心脑血管疾病的独立危险因素外，目前许多研究表明其亦与眼表疾病具有一定关联，如眼睑松弛综合征、干眼、圆锥角膜等，但尚缺少完善的系统性分析。本文拟对OSAHS与相关眼表疾病的关系，包括发病机制、临床表现、治疗进展等进行综述，以期在临床诊疗中减少OSAHS患者眼科并发症，更好地提高患者的生命质量。
[Key word]
[Abstract]
Obstructive sleep apnea hypopnea syndrome(OSAHS)is a group of diseases which occurred in the upper respiratory tract with transient, recurrent, partial or complete obstruction during night sleep. It can affect the regulation of hemodynamics, endocrine systems and autonomic nerve, and then result in the reduction of body oxygen saturation, chronic hypoxia and hypercapnia. Beside being an independent risk factor for cardiovascular and cerebrovascular diseases, many studies have shown that it is also associated with ocular surface diseases in OSAHS, such as floppy eyelid syndrome, dry eye, keratoconus, etc., but there is still a lack of perfect systematic analysis. This paper reviews the relationship between OSAHS and relevant ocular surface diseases including pathogenesis,clinical manifestations and treatment progress, in order to reduce the ophthalmic complications of OSAHS patients in clinical diagnosis and treatment,and better improve the quality of life of patients.
[中图分类号]
[基金项目]
山西省科技厅重点研发计划项目(No.201803D31095); 山西省人力资源与社会保障厅2019年省留学人员科技活动项目(No.2019-91-4); 山西省回国留学人员科研资助项目(No.2021-163)
