方法：随机选取2019-01/10于我院门诊就诊的7～15岁青少年屈光不正患者50例86眼，分为近视组(29例46眼，平均等效球镜度-2.17±1.41D)和远视组(21例40眼，平均等效球镜度1.92±1.49D)。通过光学生物测量仪(IOL Master)测量眼轴长度(AL)，通过眼前节光学相干断层扫描分析仪(SS-OCT)观察不同调节状态下(0、-3、-6D)晶状体厚度(LT)、晶状体前表面曲率半径(ALRC)、晶状体后表面曲率半径(PLRC)的动态变化。

结果：调节放松状态下(0D)，近视组LT显著小于远视组，ALRC与PLRC大于远视组(均P<0.01)，且远视组眼轴短于近视组(22.49±1.12mm vs 24.48±0.82mm，P<0.01)。随着调节刺激的增大(-3、-6D)，两组LT均显著增厚，ALRC与PLRC均显著减小(均P<0.01)。-3、-6D调节状态下，两组ALRC变化率均高于PLRC变化率(P<0.01)，但两组间LT变化率及PLRC变化率均无显著差异(P>0.05)，而远视组完成-6D调节时ALRC变化率显著大于近视组(P<0.05)。

结论：调节刺激下青少年屈光不正眼晶状体厚度增加，形态变凸，其前表面的变化程度显著大于后表面，完成大幅度调节时，远视眼晶状体前表面的形变程度显著大于近视眼。

METHODS: A random selection of 50 cases(86 eyes)of adolescents with refractive errors aged 7-15 years old who visited our clinic from January to October 2019 were divided into in myopia group(29 cases, 46 eyes, mean equivalent spherical lens was -2.17±1.41D)and hyperopia group(21 cases, 40 eyes, mean equivalent spherical lens was 1.92±1.49D). The axial length(AL)was measured by optical biometer(IOL Master). By using anterior swept source optical coherence tomography(SS-OCT), the dynamic changes of lens parameters including lens thickness(LT), anterior crystalline lens radius of curvature(ALRC)and posterior crystalline lens radius of curvature(PLRC)were observed under different accommodation stimuli(0, -3, -6D).

RESULTS: In the state of relaxed accommodation(0D), the LT of the myopia group was significantly lower than that of the hyperopia group, both ALRC and PLRC were greater than those of the hyperopia group(all P<0.01). The AL of the hyperopia group was significantly shorter than that of the myopia group(22.49±1.12mm vs 24.48±0.82mm, P<0.01). With the increase of the accommodation stimulus amplitudes(-3, -6D), the LT of the two groups increased significantly, the ALRC and PLRC both decreased significantly(all P<0.01). Under the condition of -3D and -6D, the change rate of ALRC was higher than that of PLRC in both groups(P<0.01). However, the change rate of LT and PLRC were not significantly different between the two groups(P>0.05). Furthermore, the change rate of ALRC in the hyperopia group was significantly higher than that of the myopia group when the -6D accommodation was completed(P<0.05).

CONCLUSION: During accommodation stimulation, the thickness of the lens in adolescents with refractive errors increased, the shape of the lens became convex, and the degree of change of the anterior surface was significantly greater than that of the posterior surface.