[关键词]
[摘要]
间充质干细胞(mesenchymal stem cells，MSCs)是一种来源于多种组织，具有多向细胞分化潜能和自我细胞更新的多能干细胞，可对多种眼部疾病发挥治疗作用。研究表明，MSCs的生物学功能与其分泌的外泌体(MSC-Exo)有密切联系。相较而言，MSC-Exo的生物性能更加稳定，且不具有成瘤性，因此有望成为MSCs生物学功能的有效替代物。本文对MSC-Exo在眼部疾病中的应用进展讨论，以期为MSC-Exo在眼部疾病的治疗提供思路和借鉴。
[Key word]
[Abstract]
Mesenchymal stem cells(MSCs)are pluripotent stem cells which are derived from avariety of tissues and have the potential for multidirectional cell differentiation and self-cell renewal. They can play a therapeutic effect on a variety of eye diseases. Studies have shown that the biological functions of MSCs are closely related to their secreted exosomes(MSC-Exo). Compared with MSCs, the biological performance of MSC-EXO is more stable and non-tumorigenic. Therefore, MSC-EXO is expected to be an effective substitute for the biological function of MSCs. In this paper, the application progress of MSC-EXO in ocular diseases is discussed in order to provide ideas and reference for the treatment of MSC-EXO in ocular diseases.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.81874492,81973910,81273807); 中医药防治眼耳鼻咽喉疾病湖南省重点实验室开放基金项目(No.2018YZD01,2018YZD03); 湖南中医药大学研究生科研创新基金项目(No.2018CX41,2019CX71); 湖南省中医五官科学重点学科建设项目
