诊断干眼的非侵入性新检测技术及应用价值

An overview on dry eye disease diagnosis: options for new non-invasive testing technologies

摘要:

本文对诊断干眼的非侵入性新检测技术及其在干眼诊断中的作用进行综述，其中包括泪液量、泪膜稳定性、睑板腺形态及功能、角膜形态、生物标志物、眼表温度的成像技术，以及泪液渗透压、光学质量、眨眼测试等。新的检测技术可提供客观参数以评价眼表、泪液情况及视觉质量等。泪液量、睑板腺成像和泪液渗透压等检测技术已被广泛认可并应用于临床，与传统测试相比表现出了更高的特异性和敏感性。其它检测技术，如SM技术，干涉术、光散射技术、双通道系统，眨眼测试等目前处于临床研究阶段，未来或将转化为临床常规检测技术。新的检测技术，可无创评估眼表及泪液情况，并测量与病情相关的成分变化，在干眼的诊断、分类、临床管理和疗效评估中发挥重要作用。

Abstract:

This literature review intends to provide an overview of the new non-invasive testing technologies and their role in the diagnosis of dry eye disease(DED). Including imaging technologies of tear volume, tear film stability, meibomian glands morphology and function, corneal morphology, biomarkers and ocular surface temperature, as well as tear osmolarity, optical quality, blinking test and so on. New testing technologies can provide an indirect and objective assessment of the ocular surface, tear condition and visual quality. Testing technologies, such as tear volume, meibography and tear osmolarity have been widely recognized and applied in clinical practice, showing higher specificity and sensitivity than traditional tests. Others, such as strip meniscometry, interferometer, light scattering technology, double-pass system, blinking test and so on, are currently in the stage of clinical research and improvement, and may translate to routine clinical detection techniques in the future. The new non-invasive testing technologies can non-invasively evaluate the ocular surface and tears, and measure the changes of components related to the disease, which play an important role in the diagnosis, classification, clinical management and curative effect evaluation of DED.