目的：观察妥布霉素滴眼液联合泪道冲洗探通在治疗婴幼儿泪囊炎中的应用效果。

方法：选择2018-01/2019-12期间我院收治的婴幼儿泪囊炎患儿158例174眼，根据就诊顺序随机分为观察组和对照组，观察组79例85眼，对照组79例89眼。观察组采用妥布霉素滴眼液联合泪道冲洗探通治疗，对照组单纯采用泪道冲洗探通术治疗。评价两组患儿的治疗疗效，记录并比较两组患儿泪道探通成功次数、并发症发生率、治疗前后的炎症细胞因子水平变化\〖白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、高敏C反应蛋白(hs-CRP)\〗和家属满意度。

结果：观察组疗效总有效率和一次探通成功率显著高于对照组(91.8% vs 76.4%， 94.1% vs 80.9%， P<0.05)； 治疗后观察组IL-6、TNF-α、hs-CRP炎症细胞因子水平显著低于对照组(P<0.05)； 观察组并发症发生率显著低于对照组(4.7% vs 14.6%， P<0.05)； 观察组患儿家属满意度显著高于对照组(96.2% vs 82.3%， P<0.05)。

结论：妥布霉素滴眼液联合泪道冲洗探通治疗婴幼儿泪囊炎能显著强化治疗效果，提高一次治疗成功率，控制局部感染性炎症，减少术后并发症的发生，家属满意度高。

METHODS: Totally 158 infants(174 eyes)with dacryocystitis treated in the hospital between January 2018 and December 2019 were enrolled. They were randomly divided into observation group(79 cases, 85 eyes)and control group(79 cases, 89 eyes)according to the order of treatment. The observation group was treated with tobramycin eye drops combined with irrigation and probing of lacrimal passage, while the control group was treated with irrigation and probing of lacrimal passage alone. The therapeutic effects of two groups were evaluated. The number of successful probing, incidences of complications, changes in inflammatory factors \〖interleukin 6(IL-6), tumor necrosis factor-α(TNF-α), high-sensitivity C-reactive protein(hs-CRP)\〗 before and after treatment and satisfaction of family members were compared between two groups.

RESULTS: The total response rate and the success rate of one-time probing in the observation group were significantly higher than those in the control group(91.8% vs 76.4%, 94.1% vs 80.9%, P<0.05). After treatment, the observation group had significantly lower levels of IL-6, TNF-α and hs-CRP than the control group(P<0.05). The incidence rate of complications in the observation group was significantly lower than that in the control group(4.7% vs 14.6%, P<0.05). Family members of the observation group had significantly higher satisfaction than those of the control group(96.2% vs 82.3%, P<0.05).

CONCLUSION: Tobramycin eye drops combined with irrigation and probing of lacrimal passage can effectively strengthen the curative effect on infant dacryocystitis, improve the success rate of one-time treatment, control local infectious inflammation, and reduce the incidence of postoperative complications. Besides, family members are highly satisfied.