POAG相关基因与中枢神经系统疾病的研究进展

Advances in the study of POAG-related genes and central nervous system diseases

摘要:

近年来青光眼，特别是原发性开角型青光眼(POAG)的研究取得了很大进展。一方面，通过遗传连锁分析和全基因组关联研究(GWAS)发现并确定了一系列POAG相关基因，极大地推进了青光眼遗传学的研究。另一方面，最新的观点认为青光眼是一种中枢神经系统(CNS)疾病。大量临床基础研究已证明CNS疾病与青光眼关系密切，其中遗传学方面的发现尤为突出，本文综述主要的POAG相关基因及其与CNS疾病之间的联系。

Abstract:

In recent years, considerable progress has been made in the study of glaucoma, especially primary open angle glaucoma(POAG). A series of POAG genes has been identified through genetic linkage analysis and genome-wide association studies(GWAS), which significantly advanced the study of glaucoma genetics. The latest perspective suggests that glaucoma is a disease of the central nervous system(CNS). A large number of basic clinical studies have demonstrated the close association between CNS disease and glaucoma. Among these studies, discoveries related to genetics are of prominence.