目的：系统评价中西医结合治疗外伤性视神经病变(TON)的临床疗效及安全性。

方法：通过计算机检索PubMed、Embase、Cochrane Library、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库、维普数据库自建库至2020-05的关于中西医结合与单纯西医治疗TON的随机对照研究，使用Cochrane评价手册对纳入文献进行质量评价，使用RevMan5.3统计软件进行资料提取与Meta分析。

结果：共筛选出12篇符合纳入、排除标准的文献； Meta分析结果显示，与单纯西药治疗TON比较，中西医结合治疗有效率更高\〖RR=1.33，95%CI(1.23～1.45)，P<0.001\〗； 在改善视力\〖MD=0.18，95%CI(0.14～0.23)，P<0.001\〗、视野平均缺损\〖MD=-3.08，95%CI(-5.20～0.96)，P=0.004\〗、视觉诱发电位P₁₀₀波峰潜时\〖MD=-9.47，95%CI(-16.37～2.57)，P=0.007\〗以及视觉诱发电位P₁₀₀波峰振幅\〖MD=1.44，95%CI(0.22～2.66)，P=0.02\〗上作用更显著。纳入文献有2篇提及不良反应的发生和处理，余10篇均未描述。

结论：与单纯西医治疗相比，中西医结合治疗TON的疗效更佳。

METHODS:The computer searched PubMed, EMBASE, Cochrane Library, Chinese Biomedical Literature Database(CBM), Wan-Fang Database, China National Knowledge Infrastructure(CNKI)database and Weipu database. Search time was limited from their inception to May 2020. A comprehensive search strategy was designed to identify all randomized controlled trials(RCTs)comparing TCM-WM therapy versus WM therapy alone. The methodological quality of the included trials was assessed by the quality grade evaluation used in Cochrane handbook. Data extraction and Meta-analysis were performed by RevMan5.3 statistical software.

RESULTS: Twelve RCTs were included. The Meta-analysis showed that compared with the WM therapy alone in treating TON, TCM-WM therapy was better in improving the effective rate \〖RR=1.33, 95% CI(1.23-1.45), P<0.001\〗, visual acuity \〖MD=0.18,95% CI(0.14-0.23), P<0.001\〗, visual field mean defect \〖MD=-3.08, 95% CI(-5.20-0.96), P=0.004\〗, P₁₀₀ lantency \〖MD=-9.47, 95% CI(-16.37-2.57), P=0.007\〗 as well as P₁₀₀ amplitude \〖MD=1.44, 95% CI (0.22-2.66), P=0.02\〗. Two researches reported the occurrence and treatment of adverse reactions, and the remaining included researches did not report the adverse reactions.

CONCLUSION:The TCM-WM therapy in treating TON is more effective compared with the WM therapy alone.