[关键词]
[摘要]
甲状腺相关眼病(TAO)是一种由特异性自身免疫反应引起，与甲状腺疾病密切相关的眼眶疾病。甲状腺相关眼病严重影响患者的容貌和视功能，症状重者有致盲的危险，因此给患者的工作生活带来较大困扰，而其发病机制尚未完全阐明。细胞自噬(autophagy)也称自噬，是一种吞噬自身细胞质蛋白或细胞器并将其降解，从而实现细胞本身的代谢需要和某些细胞器更新的过程。研究表明，TAO患者眼眶的自噬水平比正常人高，并对疾病的发生发展起着重要的作用。本文从炎症、脂肪形成和糖胺多糖(GAG)聚集等3个方面，简要阐述自噬在TAO的发生发展中所起的作用。
[Key word]
[Abstract]
Thyroid associated ophthalmopathy(TAO)is a type of orbital disease, it is caused by a specific autoimmune reaction, and is closely related to thyroid disease. Furthermore, TAO significantly affects the appearance and visual functionality of patients. Moreover, those with severe symptoms are at a risk of blindness, which makes it difficult for them to lead normal lives. However, its pathogenesis has not been fully established yet. Autophagy, is a process of phagocytosis and degradation of its own cytoplasmic proteins or organelles, this realizes the metabolic needs of cells and the renewal of some organelles. Previous studies have shown that, compared to normal people, the level of orbital autophagy in TAO patients is higher, and it plays an important role in the occurrence and development of the disease. This paper briefly describes the role of autophagy in the occurrence and development of TAO from three aspects, namely, inflammation, fat formation, and glycosaminoglycan(GAG)accumulation.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81360152); 广西自然科学基金资助项目(No.2018GXNSFAA281234)
