目的：探讨无菌空气填充治疗大孔径特发性黄斑裂孔的安全性和有效性。

方法：回顾性研究。共纳入2017-06/2018-05我院收治的特发性黄斑裂孔患者8例9眼，平均黄斑裂孔最小直径>700 μm，平均黄斑裂孔基底部直径>1 300 μm，所有患者均行白内障超声乳化摘除及25G玻璃体切割联合内界膜填塞、无菌空气填充术。平均随访12mo，比较术前和术后最佳矫正视力(BCVA)及黄斑裂孔闭合情况。

结果：末次随访时，所有患者黄斑裂孔均闭合，SD-OCT显示术后黄斑裂孔的闭合率为100%(9/9)。术后BCVA(LogMAR)较术前显着改善(0.83±0.26 vs 1.27±0.28)，差异有统计学意义(P=0.007)。所有患者术中及术后均未发生并发症。

结论：无菌空气填充治疗大孔径特发性黄斑裂孔安全、有效。

METHODS: A retrospective study. Nine eyes of eight patients with large IMH were admitted to our hospital from June 2017 to may 2018. Mean macular hole(MH)minimum diameter >700 μm and mean MH basal diameter >1 300 μm. All the patients were underwent 25G phacovitrectomy, internal limiting membrane flaptuck, and sterilized air tamponade in the vitreous cavity. With a mean follow up of 12mo, the best-corrected visual acuity(BCVA)and macular hole closure were compared before and after operation.

RESULTS: At the last follow up, all the patients obtained MH closure. The SD-OCT showed that the postoperative MH closure rate was 100%(9/9). Postoperative BCVA improved significantly compared with the preoperative(0.83±0.26 vs 1.27±0.28), the difference was statistically significant(P=0.007). No complications occurred during and after the operation.

CONCLUSION: Sterilized air tamponade might provide a safe and efficient effect on the closure of large IMHs.