[关键词]
[摘要]
年龄相关性黄斑变性(ARMD)是发达国家老年人不可逆性视力损害的主要原因。近几年研究发现，线粒体铁蛋白(FTMT)被认为通过铁调节起到抗氧化作用。因此，本文通过论述FTMT影响HIF-1α、FTMT基因突变、FTMT保护ARMD免受氧化应激等方面对ARMD进展过程的影响，能够更好地了解疾病的发病机制，为预防或者评价疾病做出贡献。
[Key word]
[Abstract]
Age-related macular degeneration(ARMD)is a major cause of irreversible visual impairment in the elderly in developed countries. Recent studies have shown that mitochondrial ferritin(FTMT)is thought to have an antioxidant effect through iron regulation. Therefore, this paper discusses the effects of FTMT on HIF-1α, FTMT gene mutation, and FTMT protection against oxidative stress on the progression of ARMD, so as to better understand the pathogenesis of the disease and contribute to the prevention or evaluation of the disease.
[中图分类号]
[基金项目]
黑龙江省留学归国人员科学基金(No.LC2017036)
