儿童异常瞬目与泪膜脂质层厚度关系的临床研究

Correlation between abnormal blink in children and thickness of lipid layer of tear film

摘要:

目的：检测异常瞬目儿童的泪膜脂质层厚度(LLT)，探讨儿童异常瞬目与LLT的关系，期待发现LLT在儿童异常瞬目中的诊断价值。

方法：前瞻性对比研究。选取2016-11/2017-02在我院眼科门诊主诉“频繁眨眼”为首诊原因的儿童患者46例为异常瞬目组，选取同期以非异常瞬目为主诉的儿童患者46例为对照组。分别对两组患者进行病史采集、裂隙灯检查、屈光检查、泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)检查以及用Lipiview眼表面光干涉仪测量LLT及不完全眨眼(PB)的次数并进行比较。

结果：异常瞬目组的LLT为72.17(22.13，91.00)nm，低于对照组81.97(30.25，95.27)nm(P=0.028)； 异常瞬目组双眼平均等效球镜度数(-0.98±3.09D)、SⅠt(11.39±2.46mm/5min)较对照组(-0.24±3.06D、11.74±2.10mm/5min)无差异(P>0.05)。异常瞬目组双眼平均PB(0.58±0.28)、BUT均值(18.27±5.51s)较对照组(0.43±0.17、21.01±6.14s)有差异(P<0.05)。

结论：儿童异常瞬目与多种因素相关，LLT下降，可能是儿童异常瞬目的重要因素。

Abstract:

AIM: To detect the thickness of tear film lipid layer(LLT)in children with abnormal blink, to explore the relationship between abnormal blink and LLT, and to find out the diagnostic value of LLT in children with abnormal blink.

METHODS: Prospective comparative study. Selecting 46 cases of children with "frequent blink" as the first reason in our ophthalmic outpatient clinic in 2016-11/2017-02 as abnormal blink group. In the same period, 46 children with non-anomalous blink were selected as control group. The history collection, slit lamp examination, refractive examination, Schirmer I test(SⅠt), tear film break-up time(BUT), and the number of times of LLT and incomplete blink(PB)were measured and compared surface light interferometer were compared.

RESULTS: The LLT of the abnormal blink group was 72.17(22.13, 91.00)nm, which was lower than that of the control group 81.97(30.25,95.27)nm,(U=674.5, P=0.028); The mean equivalent spherical degrees(-0.98±3.09D)and SⅠt(11.39±2.46mm/5min)in the abnormal blink group were not different from those in the control group(-0.24±3.06D, 11.74±2.10mm/5min)(P>0.05). Mean PB(0.58±0.28)and mean BUT in the eyes of blink group There was a difference(18.27±5.51s)from the control group(0.43±0.17, 21.01±6.14s)(P<0.05).

CONCLUSION: Children's abnormal blinks are associated with many factors, and the LLT decline may be an important factor in children's abnormal blink.