目的：探讨阻塞性睡眠呼吸暂停综合征(OSAS)与视网膜分支静脉阻塞(BRVO)的相关性。

方法：本研究共纳入70例BRVO患者及70例健康体检者作为对照(与BRVO患者的年龄、性别相匹配)。利用Berlin问卷对BRVO患者及对照组的OSAS患病风险进行评估，借助多导睡眠呼吸监测仪对BRVO患者及对照组的呼吸暂停低通气指数(AHI)、最小氧饱和度(MOS)等指标进行监测。根据AHI对OSAS进行诊断，对BRVO患者及对照组的OSAS发生率、平均AHI、平均MOS等指标进行比较。

结果：BRVO患者中伴发OSAS者为49例(70%)，平均AHI为19.74±7.59、MOS为(82.45±9.17)%； 对照组OSAS患者为23例(33%)，平均AHI为13.69±6.35、MOS为(88.44±8.72)%。BRVO患者及对照组OSAS的发病率、平均AHI及MOS均有差异(χ²=19.331，t=5.115、3.954，均P<0.01)。OSAS与BRVO呈正相关(r_s=0.319，P=0.033)。39例急性BRVO患者的平均AHI为16.905±6.31、MOS为(85.14±8.22)%； 31例慢性BRVO患者的平均AHI为17.84±5.47、MOS为(83.81±7.87)%，急性BRVO患者与慢性BRVO患者的平均AHI和MOS均无差异(t=0.653、0.685，P=0.516、0.496)。

结论：OSAS可能是BRVO的重要危险因素，其对于BRVO病情的持续也可能起着关键作用。

METHODS:Seventy consecutive patients with BRVO and 70 age- and sex-matched controls were evaluated retrospectively. All participants underwent Berlin questionnaire and full-night respiratory polysomnography(PSG)for estimating risk of OSAS and monitoring apnea-hypopnea index(AHI), minimal oxygen saturation(MOS).

RESULTS: Of the 70 BRVO patients, 49(70%)had OSAS,average AHI was(19.74±7.59), MOS was(82.45±9.17)%. For controls, only 23(33%)of 70 subjects had OSAS, average AHI was(13.69±6.35), average MOS was(88.44±8.72)% in controls. Incidence of OSAS, AHI and MOS between BRVO patients and controls were different significantly(χ²=19.331, t=5.115, 3.954, all P<0.01). There was a positive correlation between OSAS and BRVO(r_s=0.319, P=0.033). Of the 39 patients with acute BRVO, average AHI was(16.905±6.31), average MOS was(85.14±8.22)%. For the 31 patients with chronic BRVO, average AHI was(17.84±5.47), average MOS was(83.81±7.87)%. There were no significantly differences between acute BRVO patients and chronic BRVO patients in average AHI or MOS(t=0.653, 0.685, P=0.516, 0.496).

CONCLUSION: OSAS could be a trigger in the pathogenesis of BRVO or an important risk factor of CRVO development.