目的：探讨各种相关因素对2型糖尿病患者眼表功能的影响。

方法：收集2型糖尿病患者60例60眼为糖尿病组，非糖尿病60例60眼为对照组。分别给予行眼表疾病指数测定(OSDI)、泪液分泌(SⅠt)、泪膜破裂时间(TBUT)、泪河高度(TMH)及角膜荧光素染色(CFS)检查。

结果：所有参与者65.94%显示为干眼症状(糖尿病组为77.45%，对照组为54.43%)。糖尿病组OSDI、CFS较对照组显著升高(P<0.01)，SⅠt、TMH较对照组显著减少(P<0.05)。相关性分析结果，血糖水平、Hb1Ac、糖尿病病程对糖尿病患者的干眼症状均有所影响(P<0.05)。

结论：糖尿病患者易出现泪液分泌及泪膜功能障碍，糖尿病病程越长，血糖及Hb1Ac水平越高，泪膜稳定性越差。

METHODS: A total of 60 patients(60 eyes)with type 2 diabetes diagnosed in our hospital were chosen as diabetes group, 60 patients(60 eyes)without diabetes were chosen as control group. The subjects were tested including ocular surface disease index(OSDI), tear secretion(SⅠt)and the tear film break-up time(TBUT), tear meniscus height(TMH), corneal fluorescein staining(CFS).

RESULTS: All 65.94% of participants emerged dry eye(77.45% diabetics and 54.43% controls). In the diabetic group,OSDI and CFS were significantly higher(P<0.01), and BUT,SⅠt and TMH were significantly lower(P<0.05). Related analysis showed that duration of diabetes, glycemia and Hb1Ac were the influencing factors of symptoms in diabetic patients(P<0.05).

CONCLUSION: Diabetes patients are inclined to dysfunction in tear secretion and tear film, the longer of diabetes,and the higher of the glycemia and Hb1Ac, the worse the tear film stability were.