[关键词]
[摘要]
视网膜静脉阻塞(RVO)分为视网膜分支静脉阻塞和视网膜中央静脉阻塞，是以视网膜静脉扩张迂曲、血流瘀滞、出血和水肿为特征的病变，常并发黄斑水肿和新生血管，新生血管型青光眼是其最严重的并发症。视网膜静脉阻塞对视力危害较大，是仅次于糖尿病性视网膜病变的第二大致盲性眼病。目前为止，视网膜静脉阻塞的患病人数增多，但其发病机制尚未完全明了，而且也无长久有效的治疗方法。实验室中动物模型对视网膜静脉阻塞发病机制和治疗方法的研究至关重要，因此本文对视网膜静脉阻塞实验中使用的动物及模型的制作方法做了简要综述，并对各种视网膜静脉阻塞动物模型的优缺点进行讨论。
[Key word]
[Abstract]
Retinal vein occlusion(RVO)is divided into branch retinal vein occlusion and central retinal vein occlusion. It is characterized by retinal vein dilatation and tortuosity, blood flow stasis, bleeding and edema. It is often accompanied by macular edema(ME)and neovascularization. Neovascular glaucoma is the most serious complications. RVO is the second most common cause of visual loss classified under retinal vascular disorders after diabetic retinopathy. So far, the number of patients suffering from retinal vein occlusion has increased, but the pathogenesis of retinal vein occlusion has not been fully understood and there are no treatments that are very long-lasting. The research of animal models on the pathogenesis and treatment of the RVO is very important. Therefore, this article gives a briefly review to the animals and model making methods used in retinal vein occlusion experiments, and discusses the advantages and disadvantages of various RVO animal models.
[中图分类号]
[基金项目]
国家自然科学基金青年基金(No.81603666); 北京市自然科学基金(No.7192235); 北京中医药科技发展资金项目(No.JJ2018-95); 首都临床特色应用研究重点研发项目(No.Z181100001718183)
