持续性角膜上皮缺损的治疗进展

Progress in research on persistent corneal epithelial defects

摘要:

持续性角膜上皮缺损(PED/PCEDs)是指角膜损伤后10～14d内，在接受了相应治疗后，角膜也未能迅速重新形成上皮并闭合而导致的一种角膜疾病。角膜上皮的破坏和基质层的损伤容易使眼部受到感染、发生基质溃疡、穿孔、瘢痕，甚至丧失视力。就目前而言，临床医生对PED的治疗仍然面临相当大的挑战。标准的治疗方法包括配戴绷带隐形眼镜和使用人工泪液治疗，而新开发的药物则可以通过促进各类生长因子的生成使角膜重新形成上皮，进一步配合相应外科手术为角膜提供神经支配，以此达到治疗的效果。此外，确诊PED后应尽早接受治疗，以避免继发性并发症。本文就PED的流行病学、病因学、诊断与临床表现、治疗方法及预后进行综述。

Abstract:

Persistent corneal epithelial defect(PED/PCEDs)is an eye disease that fails to form corneal epithelium rapidly even after 10-14d of corneal injury. Corneal protective epithelial destruction and stromal layer damage can easily lead to eye infection, stromal ulcer, perforation, scar formation, and even blindness. At present, clinicians still face considerable challenges in treating PED patients. Standard treatments such as wearing bandaged contact lenses and using artificial tears, while newly developed drugs can promote the formation of various growth factors to re-form the cornea, and further cooperate with the corresponding surgery to provide innervation for the cornea. In order to achieve the effect of treatment. In addition, treatment should be carried out as soon as possible after the diagnosis of PED to avoid secondary complications. This article reviews the epidemiology, etiology, diagnosis, clinical manifestation, treatment and prognosis of persistent corneal epithelial defect.