长链非编码RNA在眼部疾病中的作用

Research progress on the role of long non-coding RNAs in eye diseases

摘要:

长链非编码RNA(LncRNAs)是指长度大于200个核苷酸且不能编码蛋白质的RNA。随着新一代高通量测序技术的应用，对全基因组分析表明，LncRNAs可以调节免疫应答、表观遗传、基因转录及转录后水平的基因表达，从而参与维持细胞的增殖与凋亡、组织内稳态等生理过程。近年来研究发现LncRNAs与人体多种疾病的发生发展相关。本文主要就LncRNAs在眼科常见疾病中的研究进展进行综述，以期对相关眼科疾病进行早期诊断与治疗。

Abstract:

Long non-coding RNAs(LncRNAs)refer to RNAs that are longer than 200 nucleotides and cannot encode a protein. With the application of next-generation sequencing technology, whole-genome analysis shows that LncRNAs can regulate gene expression in immune response, epigenetic, gene transcription and post-transcriptional levels, thereby participating in the maintenance of cell proliferation and apoptosis, tissue homeostasis and other physiological processes. LncRNAs have been shown to involve in initiation and development of a variety of human diseases in recent years. This article reviews the research progress of LncRNAs in common diseases of ophthalmology, in order to early diagnosis and treatment of related ophthalmic diseases.