目的：研究合肥地区2型糖尿病患者尿微量白蛋白肌酐比值(UACR)与糖尿病视网膜病变(DR)的关系。

方法：回顾性病例分析。选取2018-11/2019-09于我院治疗的2型糖尿病患者281例，根据眼底摄片结果将患者分为DR组和非DR(NDR)组，采集患者性别、年龄、糖尿病病程、高血压史、体质量指数(BMI)、UACR、空腹血糖、糖化血红蛋白、总胆红素、总胆固醇、甘油三酯、血尿素等资料，分析DR发生的危险因素。

结果：本研究纳入患者中，检出NDR患者169例(60.1%)，DR患者112例(39.9%)。Logistic回归分析及受试者工作特征曲线(ROC曲线)分析结果显示，DR发生相关危险因素为UACR(β=0.036，OR=1.037，95%CI 1.019～1.056，P<0.001)，最佳临界值为10.15mg/g·Cr(AUC=0.717，P<0.001)； 糖尿病病程(β=0.061， OR=1.063，95%CI 1.008～1.120，P=0.023)，最佳临界值为10.5a(AUC=0.666，P<0.001)。

结论：UACR及糖尿病病程是合肥地区部分2型糖尿病患者DR发生的独立危险因素。

METHODS: A retrospective case analysis. 281 patients with type 2 diabetes mellitus(T2DM)hospitalized in Hefei Second People's Hospital from November 2018 to September 2019 were conducted in this study. According to the digital fundus photography, the patients were divided into diabetic retinopathy group(DR group)and non-diabetic retinopathy group(NDR group). The patients' gender, age, course of diabetes, history of hypertension, body mass index(BMI), blood urea nitrogen(BNU), urinary microalbumin creatinine ratio(UACR),fasting blood glucose, HbA1c, total bilirubin(TB), total cholesterol(TC), triglyceride(TG)were collected and risk factors of DR were analyzed.

RESULTS: A total of 281 cases, 169(60.1%)were in the NDR group and 112(39.9%)in the DR group. Logistic regression analysis and ROC curve analysis showed that the risk factors related to DR were UACR(β=0.036, OR=1.037, 95% CI: 1.019-1.056, P<0.001), the best critical value was 10.15mg/g·Cr(AUC=0.717, P<0.001); the course of diabetes(β=0.061, OR=1.063, 95% CI: 1.008-1.120, P=0.023), the best critical value was 10.5a(AUC=0.666, P<0.001).

CONCLUSION: UACR and the course of diabetes are independent risk factors for DR in some of the patients with type 2 diabetes in Hefei.