[关键词]
[摘要]
视网膜新生血管形成是许多视网膜疾病的病理特征，例如早产儿视网膜病变和糖尿病视网膜病变，可导致严重的视力丧失甚至失明。抑制视网膜新生血管形成是治疗这些视网膜疾病的治疗策略。目前，已存在几种抑制视网膜新生血管形成的治疗策略，包括激光封闭、抑制血管内皮生长因子(VEGF)以及干细胞的移植等。随着干细胞研究的深入，发现干细胞治疗尽管潜力极大，但亦存在如移植细胞的低生存力，先天异质性等技术障碍，目前研究发现来源于间充质干细胞(MSCs)的外泌体具有与MSCs相似的功能，且尺寸小、易于通过生物膜，为细胞治疗提供了一种新思路，本文就外泌体对视网膜新生血管疾病的最新进展作一综述。
[Key word]
[Abstract]
Retinal neovascularization is a pathological feature of many retinal diseases, such as retinopathy of prematurity and diabetic retinopathy, which can lead to severe vision loss or even blindness. Inhibition of retinal neovascularization is a therapeutic strategy for the treatment of these retinal diseases. At present, there are several therapeutic strategies for inhibiting retinal neovascularization, including laser blocking, inhibition of vascular endothelial growth factor(VEGF), and transplantation of stem cells. With the deepening of stem cell research, people find that although stem cell therapy has great potential, there are also technical obstacles such as low viability of transplanted cells and congenital heterogeneity. Current studies have found exosomes derived from mesenchymal stem cells(MSCs). They have similar functions as MSCs, and their sizes are small and easy to pass through biofilm, which provides a new idea for cell therapy. This paper reviews the recent progress of exosomes on retinal neovascular diseases.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81770948)
