目的：观察青少年高度近视患者高阶像差、屈光度、眼部结构参数及其相关性。

方法：横断面研究。选取2019-07/09在我院视光学中心验光门诊就诊的青少年高度近视患者116例116眼，均进行主觉验光，检测眼轴和眼压，并采用Sirius三维眼前节分析仪测量高阶像差\〖总像差(RMSg)、总高阶像差(RMSh)、Z22(90°/180°方向散光)、Z33(三叶草Trefoil)、Z31(水平位彗差)、Z40(球差)、三阶～七阶像差(RMS3～RMS7)\〗、角膜曲率(角膜最小屈光力K1、角膜最大屈光力K2、角膜平均屈光力Km)、中央角膜厚度(CCT)、前房深度(ACD)、前房角(ACA)，分析上述眼部参数之间的相关性。

结果：青少年高度近视患者屈光度与眼轴呈负相关(r=-0.400，P<0.001)； 眼轴与前房深度呈正相关(r=0.433，P<0.05)，与角膜曲率(K1、K2、Km)呈负相关(P<0.05)； 总高阶像差与屈光度呈负相关(r=-0.189，P<0.05)，与眼轴呈负相关(r=-0.228，P<0.05)； 各高阶像差与球镜度无相关性(P>0.05)，球差Z40与角膜曲率(K1、K2、Km)呈正相关(P<0.05)，未发现高阶像差与CCT、ACD、ACA具有相关性。

结论：青少年高度近视患者随着近视程度的增加，眼轴及总高阶像差增加，且总高阶像差与眼轴呈负相关，眼轴的增长可能是减少高阶像差的一种代偿方式，促进近视的发展。

METHODS: Cross sectional study. Totally 116 adolescent high myopia patients(116 eyes)were selected from the Center of Optometry of the First Affiliated Hospital of Harbin Medical University on July 9, 2019. The axial length and intraocular pressure were measured. The high-order aberrations(RMSg, RMSh, Z22, Z33, Z31,Z40,RMS3-RMS7), corneal curvature(minimum K1, maximum K2, average km), central cornea thickness(CCT), anterior chamber depth(ACD)and anterior chamber angle(ACA)were measured with Sirius three-dimensional anterior segment analyzer. The correlation between the above eye parameters was analyzed.

RESULTS: There was a significant negative correlation between diopter and axial length(r= -0.400, P<0.001); a positive correlation between axial length and anterior chamber depth(r= 0.433, P<0.05), a negative correlation between axial length and corneal curvature(K1, K2, Km)(P<0.05); a negative correlation between total higher-order aberrations and diopter(r=-0.189, P<0.05), which was negatively correlated with the axial length(r=-0.228, P<0.05). There was no correlation between the higher-order aberrations and the sphericity(P>0.05), Z40 was positively correlated with the corneal curvature(K1, K2, Km)(P<0.05), and no correlation between higher-order aberrations and CCT, ACD, ACA was found.

CONCLUSION: With the increase of myopia degree, the axial length and total higher-order aberrations of adolescent high myopia increase, and the total higher-order aberrations are negatively correlated with the axial length. The increase of axial length may be a compensatory way to reduce the high-order aberrations and promote the development of myopia.