[关键词]
[摘要]
在各种眼科疾病，如青光眼、黄斑变性等疾病的发生发展中，细胞氧化应激的发生非常常见，氧化应激可以使细胞受损而凋亡。Sirtuins家族(Ⅲ类组蛋白去乙酰化酶)作为一类多种细胞的调控因子，在人体各种器官中广泛表达。Sirtuins的同源基因(SIRT1)在眼部也广泛表达，其表达与激活可以起到抗氧化应激的作用，防止细胞衰老及损伤，进而防止疾病的进展。本文就Sirtuins家族在青光眼、年龄相关性黄斑变性、视神经炎、年龄相关性白内障中的作用机制与表达进行论述。
[Key word]
[Abstract]
In a variety of eye diseases, such as glaucoma, macular degeneration and other diseases, the occurrence of oxidative stress is very common, oxidative stress can cause cell damage and apoptosis. The Sirtuins family(histone class III deacetylases), as regulators of a variety of cells, is widely expressed in various organs of the human body. Homologous genes of sirtuins(SIRT1)are also widely expressed in the eyes, and their expression and activation can play an anti-oxidative stress role, prevent cell senescence and damage, and thus prevent the progression of disease. This paper discusses the mechanism and expression of Sirtuins family in glaucoma, senile macular degeneration, optic neuritis and senile cataract.
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[基金项目]
国家自然科学基金资助(No.81660158,81400372); 江西省重点研发项目(No.20151BBG70223); 江西省卫计委科技计划面上项目(No.20175116)
