[关键词]
[摘要]
高迁移率蛋白家族(high mobility group box，HMGB)因其在电泳中的高迁移率而得名，其中对高迁移率蛋白1(high mobility group box 1，HMGB1)的研究最为深入。研究表明，胞外HMGB1作为损伤相关分子模式(damage-associated molecular pattern，DAMP)参与多种常见眼部疾病——干眼、角膜病、青光眼、葡萄膜炎、糖尿病性视网膜病变、年龄相关性黄斑变性的组织损伤修复的病理生理过程，从而对疾病的愈合产生负性影响。沉默胞外HMGB1的功能有望成为这些眼科疾病新的治疗手段。本文就胞外HMGB1在常见眼科疾病中的研究进展作一综述。
[Key word]
[Abstract]
High mobility group box 1(HMGB1), which belongs to a high mobility group box that known for high mobility in electrophoresis, has been researching most intensively. Recently, researches have revealed that extracellular HMGB1, as a damage-associated molecular pattern(DAMP), is involved in the pathophysiology of tissue damage repairin a variety of common ocular diseases, namely, dry eye, keratopathy, glaucoma, uveitis, diabetic retinopathy, and age-related macular degeneration, thereby negatively affecting the healing of the disease. Silencing the function of extracellular HMGB1 is expected to be a new way for these ophthalmic diseases. This thesis reviews the research progress of extracellular HMGB1 in common ophthalmic diseases.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81170828,81670837); 天津市应用基础与前沿技术研究计划项目(No.15JCZDJC35300); 天津市卫计委科技攻关项目(No.14KG133)
