[关键词]
[摘要]
研究表明，眼球表面上皮细胞中高度糖基化的黏蛋白和半乳糖凝集素-3共同形成的糖萼屏障对眼球表面湿润性和润滑性的维持十分重要。而干眼患者眼球表面湿润性降低及泪膜破裂时间缩短与糖萼屏障的损伤密切相关。本文旨在概述眼球表面糖萼屏障的组成及其在干眼中的变化，介绍评估干眼患者糖萼屏障损伤的新方法，并对目前使用的两种靶向治疗干眼患者眼球表面糖萼屏障损伤的药物进行综述。
[Key word]
[Abstract]
Some studies have shown that the glycocalyx barrier formed by highly glycosylated mucin and galectin-3 in the epithelial cells of the eyeball is important for the maintenance of moisturization and lubrication of the surface of the eye. The decrease in the wettability of the eye surface and the shortening of the tear film breakup time in dry eye patients are closely related to the damage of the glycocalyx barrier. This article outlines the composition of the glycocalyx barrier on ocular surface and its changes in the dry eye patients. It will also introduce a new method for assessing the damage of the glycocalyx barrier in dry eye patients. Finally, two ophthalmological drugs, which target regulating the abnoemality of transmembrane mucins in dry eye disease will be mentioned.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81660158); 江西省自然科学基金重大项目(No.20161ACB21017)
