[关键词]
[摘要]
年龄相关性白内障是一种由于晶状体混浊而影响视力的致盲眼病，居世界首位。氧化应激下晶状体上皮细胞凋亡相关信号转导通路的激活是介导年龄相关性白内障的主要机制。细胞凋亡有许多相关的信号转导通路，是一个复杂的网络系统。本文总结介导年龄相关性白内障不同的凋亡细胞信号转导通路，为进一步研究奠定基础。
[Key word]
[Abstract]
Age-related cataract is a blinding eye disease that affects vision due to opacity of intraocular lens, ranking first in the world. Under oxidative stress, the activation of apoptosis related signal transduction pathways in lens epithelial cells is the main mechanism mediating age-related cataract. There are many related signaling pathways for apoptosis, and it is a complex network system. The purpose of this literature review is to summarize different apoptotic cell signal transduction pathways that mediate age-related cataract, laying the foundation for further researching.
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[基金项目]
国家自然科学基金(No.31601116); 牡丹江医学院研究生创新科研项目(No.2019YJSCX-10MY)
