目的：分析玻璃体切割术(PPV)后发生角膜上皮病变(CED)的危险因素。

方法：回顾性分析2016-07/2018-06于我院行PPV术的患者235例235眼的临床资料，收集患者年龄、性别、相关病史资料(如眼部病变、全身疾病)，记录术中眼内填充物、手术时间、术后眼压等情况，采用Logistic回归分析PPV术后发生CED的危险因素。

结果：本研究纳入患者PPV术后CED发生率为16.6%(39/235)，持续性角膜上皮病变发生率为1.3%(3/235)。Logistic回归分析结果显示年龄、术前合并干眼、糖尿病、术中硅油填充、术后高眼压及手术时间是导致PPV术后发生CED的危险因素(OR=1.270、5.218、18.598、4.659、10.799、1.104，均P<0.05)。

结论：患者年龄、术前合并干眼、糖尿病、术中硅油填充、手术时间及术后高眼压是PPV术后发生CED的危险因素。

METHODS: Clinical data of 235 patients with 235 eyes of PPV from July 2016 to June 2018 in our hospital were retrospectively analyzed. The age, sex and related medical history of the patients(such as ocular lesions and systemic diseases)were collected, and the intraocular fillers, operation time, postoperative intraocular pressure were recorded. Logistic regression was used to analyze the risk factors of CED after PPV.

RESULTS: The incidence of CED after PPV was 16.6%(39/235), and the incidence of persistent corneal epithelial lesion was 1.3%(3/235). Logistic regression showed that age, preoperative xerophthalmia, diabetes mellitus, Silicone oil filling, postoperative high intraocular pressure and operation time were risk factors for CED after PPV. The OR values were 1.270, 5.218, 18.598, 4.659, 10.799 and 1.104, respectively.

CONCLUSION: Age, preoperative xerophthalmia, diabetes mellitus, silicone oil filling, postoperative high intraocular pressure and operation time are risk factors for CED after PPV.