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[摘要]
目的：研究2014/2018年浙江苍南县新生儿眼部感染病原菌分布、常用抗生素耐药性及流行特征，为临床病情的预防、诊断与治疗提供依据。
方法：将本院2014-01/2018-12新生儿门诊294份眼部标本中分离所得108株病原菌进行鉴定、常用药物敏感试验和流行病特征汇总分析。
结果：眼部分泌物标本294份中病原菌检出率为36.7%(108/294)。主要菌群包括表皮葡萄球菌48株(44.4%)，金黄色葡萄球菌16株(14.8%)，大肠埃希菌24株(22.2%)，淋病奈瑟菌12株(11.1%)，类白喉棒状杆菌5株(4.6%)，肠球菌属2株(1.9%)，链球菌属1株(0.9%)。主要病原菌对阿米卡星和奈替米星具有高度敏感性，对洁霉素和庆大霉素活性较差。对喹诺酮类抗生素活性较好。
结论：新生儿眼部感染的致病菌以葡萄球菌属为主，临床常用眼部抗菌药物对各类病原菌具有良好的抗菌活性。
[Key word]
[Abstract]
AIM:To study the distribution, drug resistance and epidemic characteristics of pathogenic bacteria in neonatal eye infection in Cangnan County, Zhejiang Province from 2014 to 2018, and to provide the basis for the prevention, diagnosis and treatment of clinical conditions.
METHODS: Totally 108 strains of pathogenic bacteria isolated from 294 eyes specimens from neonatal clinic from January 2014 to December 2018 were identified, common drug sensitivity test and epidemiological characteristics were summarized and analyzed.
RESULTS: The detection rate of pathogenic bacteria in 294 ocular secretions was 36.7%(108/294). The main flora included 48 strains of Staphylococcus epidermidis(44.4%), 16 strains of Staphylococcus aureus(14.8%), 24 cases of Escherichia coli(22.2%), 12 strains of Neisseria gonorrhoeae(11.1%), 5 strains of Corynebacterium diphtheria(4.6%), 2 strains of Enterococcus(1.9%)and 1 case of Streptococcus (0.9%). The main pathogens are highly sensitive to amikacin and netilmicin, and are highly sensitive to jellithromycin and netilmicin. The activity of gentamicin is poor. It has good activity against quinolones.
CONCLUSION:Staphylococcus is the main pathogen of neonatal eye infection, and eye antibiotics commonly used in clinic have good antibacterial activity against all kinds of pathogenic bacteria.
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