[关键词]
[摘要]
阈下微脉冲激光(SML)是一种短促重复的脉冲激光，与传统激光相比，SML不会破坏视网膜色素上皮(RPE)细胞，也不会留下激光斑，是一种相对安全的治疗手段。SML可能的作用机制是通过重复的阈值下能量激活RPE细胞，促使热休克蛋白表达增加，从而启动RPE细胞的调节修复功能。目前SML的适应证主要有中心性浆液性脉络膜视网膜病变、糖尿病性黄斑水肿、视网膜静脉阻塞继发黄斑水肿、重度非增殖期糖尿病视网膜病变和增殖期糖尿病视网膜病变。本文旨在综述SML的作用机制及其在各适应证中的应用，以期为SML的临床应用提供参考。
[Key word]
[Abstract]
Subthreshold micropulse laser(SML)consists of short repetitive pulses of laser. This kind of treatment is safe and cheap, and contrary to conventional laser photocoagulation(LPC), SML doesn't involve destruction of retinal cells and leave no scars. The possible mechanism of SML is to stimulate retinal pigment epithelium(RPE)cells for the production of heat shock proteins(HSPs)and regulate its metabolism and improve its function. The clinical indication of SML includes central serous chorioretinopathy(CSC), diabetic retinopathy edema(DME), nonproliferative diabetic retinopathy(NPDR)and proliferative diabetic retinopathy(PDR)and macular edema(ME)secondary to retinal vein occlusion(RVO). This article discussed the mechanism and safety of SML and reviewed the updates of its application.
[中图分类号]
[基金项目]
云南省科技厅-昆明医科大学应用基础研究联合专项资金项目\〖No.2017FE467(-146),2018FE001(-077)\〗; 白求恩·朗沐中青年眼科科研基金(No.BJ-LM2018009J)
