目的：探讨妥布霉素地塞米松眼膏联合缘螨净茶树油清洁湿巾治疗蠕形螨睑缘炎的治疗效果。

方法：前瞻性临床研究。选取蠕形螨睑缘炎患者72例，随机分为3组，试验组给予妥布霉素地塞米松眼膏联合缘螨净茶树油清洁湿巾治疗，对照1组给予妥布霉素地塞米松眼膏联合茶树油眼膏治疗，对照2组给予茶树油眼膏治疗。治疗30d后，对患者进行症状评分、拔睫毛螨虫计数及裂隙灯下观察临床体征评分。比较三组治疗前后数据。

结果：三组治疗前后蠕形螨计数均有差异(P<0.01)，症状总评分差值有差异(F=20.05，P<0.01)，体征总评分差值有差异(F=8.10，P<0.01)。

结论：妥布霉素地塞米松眼膏联合缘螨净茶树油清洁湿巾治疗蠕形螨睑缘炎疗效显著，茶树油清洁湿巾具有便携、易保存、不易变质的特点。

METHODS: Prospective clinical study. Totally 72 patients with demodex blepharitis were selected. They were randomly divided into three groups. The experimental group was treated with tobramycin dexamethasone eye ointment combined with OCuSOFT tea tree oil cleaning wipes. After 30d of treatment, the symptom score, the number of eyelash mites and the score of clinical signs were observed under slit lamp. The data before and after treatment were compared by paired sample t-test and analysis of variance.

RESULTS: There was significant difference in demodex count among the three groups before and after treatment(P<0.01). The difference of total symptom score was statistically significant(F=20.05, P<0.01). The difference of total score of physical signs was statistically significant(F=8.10, P<0.01).

CONCLUSION: Tobramycin dexamethasone eye ointment combined with OCuSOFT tea tree oil cleaning wipes is effective in the treatment of demodex blepharitis. Tea tree oil cleaning wipes are portable,easy to preserve and not easy to deteriorate.