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[摘要]
非甾体抗炎滴眼液常用于眼表、眼前段及眼术后炎症的抗炎镇痛治疗。作为新一代非甾体抗炎药,溴芬酸钠因其独特的化学结构,使其既是一种强效抗炎药,又是一种可渗透到眼部组织中的亲脂分子,从而增加作用的持续时间。溴芬酸钠滴眼液作为一种抗炎药,在治疗白内障和屈光手术后眼部疼痛及炎症方面有着广泛的全球安全记录。目前,学者还开发出溴芬酸钠滴眼液除了抗炎、镇痛外的其他眼科应用,发现溴芬酸钠滴眼液具有强效、安全且便利的特点。本文归纳了溴芬酸钠滴眼液在眼科中的应用进展及前景,以期为今后的临床治疗提供新思路。
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[Abstract]
Topical ophthalmic nonsteroidal anti-inflammatory drugs(NSAIDs)are used to treat ocular surface and anterior segment inflammation as well as postoperative management of pain and inflammation. As a new generation of NSAIDs, because of its unique molecule structure, bromfenac is both a kind of potent anti-inflammatory drug and a lipophilic molecule that can penetrate ocular tissues and as a result increase the duration of action. Bromfenac has an extensive global safety record as an anti-inflammatory drug, as well as in the management of ocular pain and inflammation following cataract and refractive surgery. Apart from the functions mentioned above, nowadays researchers have also discovered other ophthalmic applications of bromfenac sodium, and therefore reach a conclusion that bromfenac sodium eye drops are safe, effective and convenient in terms of ophthalmic treatment.This review summarizes recent application progress of bromfenac sodium eye drops in ophthalmology, and then gives prospect about its future application, hoping to provide a new idea for the clinical treatment in ophthalmology in the future.
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