目的：运用Meta分析方法对青光眼术后采用神经生长因子(NGF)治疗的疗效进行系统性评价。

方法：按Cochrane系统评价方法，全面检索数据库，纳入2015-01/2019-02关于青光眼术后采用NGF治疗的随机对照研究，使用Revman 5.3统计软件进行资料提取与Meta分析。

结果：共纳入6项随机对照研究，均为中文文献，共计患者513例。疗程结束后，其中5项研究进行了视力检测，6项研究进行了眼压检测，差异均无统计学意义\〖MD=0.10，95%CI(-0.05，0.25)，P=0.19； MD=-0.90，95%CI(-1.92，0.11)，P=0.08\〗； 5项研究进行了视野检测，3项研究进行了图像视觉诱发电位(VEP)检测(P100波潜伏期、P100波振幅)，差异均有统计学意义\〖MD=-2.49，95%CI(-4.02，-0.96)，P=0.001； MD=-12.13，95%CI(-17.30，-6.97)，P<0.001； MD=1.34，95%CI(0.93，1.74)，P<0.001\〗。

结论：NGF对青光眼患者术后视力改善，眼压降低的效果不明显，但对改善视野、VEP P100波潜伏期、P100波振幅的作用明显，具有一定的治疗优势。

METHODS: Comprehensive computer search database according to Cochrane systematic evaluation method. Randomized controlled trials of glaucoma after NGF treatment in the past 5a were included, the data extraction and Meta-analysis were performed by using Revman 5.3 statistical software.

RESULTS: A total of 6 cases randomized controlled trials were included, all of which were in Chinese, totally 513 cases. At the end of the treatment period, visual acuity was detected in 5 of the studies and 6 studies were performed with intraocular pressure, the difference among cases and normal were not statistically significant \〖MD=0.10,95%CI(-0.05,0.25),P=0.19; MD= -0.90, 95%CI (-1.92, 0.11), P=0.08\〗; 5 studies were performed on the visual field and 3 studies performed visual evoked potential(VEP), included P100 wave latency and P100 wave amplitude, the difference was statistically significant \〖MD= -2.49, 95%CI (-4.02, -0.96), P=0.001; MD= -12.13, 95%CI (-17.30, -6.97), P<0.001; MD=1.34, 95%CI (0.93, 1.74), P<0.001\〗.

CONCLUSION: NGF can improve the visual field of patients with glaucoma, and also can improve image visual evoked potential P100 wave latency and P100 wave amplitude. However, the effect of improving visual acuity and reducing intraocular pressure is not obvious. In a word, the NGF can ameliorate the optic neuropathy.