目的：探讨FS-LASIK设置6.0mm和6.5mm两种光学区直径对术后视觉质量的影响。

方法：本研究为前瞻性研究。选取行FS-LASIK手术的患者25例50眼，随机预设置患者双眼光学区切削直径6.0mm或6.5mm，并按光学区直径分为6.0mm及6.5mm两组。术后3mo对两组患者进行Sirius三维眼前节分析系统测量角膜高阶像差(包括3、5、7mm瞳孔直径下的总高阶像差、球差、彗差及三叶草差)以及OQASⅡ视觉质量分析仪比较MTF截止空间频率(MTF cut off)、斯特列尔比值(SR)和客观散射指数(OSI)、不同模拟对比度视力(OV100%、OV20%、OV9%)，并对两组患者进行OSDI干眼相关视觉质量主观问卷调查。

结果：术后3mo，3mm瞳孔直径下，两组总高阶像差、球差、彗差及三叶草差无差异(均P>0.05)； 5mm瞳孔直径下，两组总高阶像差、彗差、三叶草差无差异(均P>0.05)，但球差有差异(P<0.05)； 7mm瞳孔直径下，两组总高阶像差、球差均有差异(均P<0.05)，但彗差、三叶草差无差异(均P>0.05)。两组的OSDI问卷评分及OQASⅡ客观视觉质量各项参数均无差异(均P>0.05)。

结论：6.5mm光学区直径FS-LASIK术后暗环境的高阶像差较小，但术前设置6.0mm光学区直径或6.5mm光学区直径均能获得良好的主观及客观视觉质量。

METHODS: This was a prospective study. Totally 25 patients(50 eyes)treated with FS-LASIK were included and they were classified into 6.0mm group and 6.5mm group according to optical zone. Objective visual quality was evaluated by OQASⅡoptical quality analysis system(including OSI, Strel Ratio, MTF cut off, OV100%, OV20%, OV9%)and by Sirius to obtain the higher order aberrations parameters(including total HOAs, spherical aberrations, trefoil and coma)at 3mm, 5mm and 7mm pupil sizes. OSDI questionnaire was applied to evaluate patients' subjective visual quality.

RESULTS: At 3mo postoperatively, there were no significant differences in total HOAs, spherical aberrations, trefoil and coma under 3mm pupil size(all P>0.05). Significant differences were only observed in spherical aberrations at 5mm pupil size(P<0.05), and in total HOAs and spherical aberrations at 7mm pupil size(P<0.05).However, there were no significant differences in OSDI scores and OQAS visual quality parameters(P>0.05).

CONCLUSION: HOAs under scotopic conditions could be less with 6.5mm optic zone after FS-LASIK, however, both 6.0mm and 6.5mm optical zones could achieve good subjective and objective visual quality after FS-LASIK.