目的：系统评价眼周穴位雷火灸对干眼症的临床疗效和安全性，为后续眼周穴位雷火灸的临床应用提供循证研究依据。

方法：计算机检索Pubmed、Embase、Cochrane Library、维普中文科技期刊数据库、中国知网、万方数据库，查找国内外采用眼周穴位雷火灸对干眼症的随机对照试验(RCT)。由2位研究成员根据纳入与排除标准独立筛选文献、提取资料和评价质量后，采用Review Manager5.3软件进行Meta分析。

结果：最终纳入7个RCT，共计患者530例，其中治疗组265例，对照组265例。Meta分析结果显示：眼周穴位雷火灸治疗干眼症在临床疗效、SⅠt、BUT方面均优于对照组：临床疗效：OR=2.44，95%CI(1.74～3.43)，P<0.001； SⅠt：WMD=0.87，95%CI(0.46～1.27)，P<0.001； BUT：WMD=1.44，95%CI(1.01～1.86)，P<0.001。

结论：眼周穴位雷火灸可有效改善干眼症患者的泪液分泌及泪膜破裂时间，该疗法安全有效。

METHODS: Found a randomized controlled trial for the treatment of xerophthalmia with Thunder-Fire Moxibustion and massage acupoints around eyes by the retrieval from Pubmed, Embase, Cochrane Library, China Science and Technology Journal Database, CNKI and Wanfang Data. After two researchers independently screened the literature, extracted the data and evaluated the quality according to the inclusion and exclusion criteria, Review Manager 5.3 was applied to process Meta-analysis.

RESULTS: Finally, seven RCT were selected for this Meta-analysis, a total of 530 patients,including 265 patients in the treatment group and 265 patients in the control group. The results showed that the clinical efficacy in the treatment group was better than that in the control group(OR=2.44, 95% CI: 1.74-3.43; P<0.001). And the SⅠt in the treatment group was superior to that in the control group(WMD = 0.87, 95% CI: 0.46-1.27; P<0.001). And the BUT in the treatment group was longer than that in the control group(WMD= 1.44, 95% CI: 1.01-1.86; P<0.001).

CONCLUSION: Thunder-Fire Moxibustion and massage acupoints around eyes can improve the SⅠt and BUT of xerophthalmia. The therapy is not only safe and effective, but suitable for wider use as well.