原发性双眼翼状胬肉与高脂血症的关系研究

Study on relationship between bilateral primary pterygium and hyperlipidemia

摘要:

目的：探讨原发性双眼翼状胬肉与高脂血症之间的关系。

方法：回顾性分析原发性双眼翼状胬肉患者(胬肉组)40例和健康体检者(对照组)40例，胬肉组按翼状胬肉分级分为1级(Group1)、2级(Group2)和3级(Group3)。所有研究对象空腹抽静脉血检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(APOA1)和载脂蛋白B(APOB)。比较胬肉组与对照组、翼状胬肉分级组间的血脂水平。

结果：胬肉组TC、LDL-C和APOB高于对照组(P=0.024、0.012、0.009)； 胬肉组TG高于对照组，HDL-C和APOA1低于对照组，但均无差异(P>0.05)。三组翼状胬肉分级组间LDL-C差异有统计学意义(2.76±0.57、3.40±0.96、3.85±1.16mmol/L，P=0.036)，而其余指标比较无差异(P>0.05)； Group3组LDL-C高于Group1(P=0.012)。

结论：原发性双眼翼状胬肉与高脂血症之间关系密切，可能是其发病的危险因素之一。

Abstract:

AIM: To explore the relationship between bilateral primary pterygium and hyperlipidemia.

METHODS: The retrospective study included 40 patients with bilateral primary bilateral pterygium(pterygium group)and 40 healthy subjects(control group). Pterygium was graded clinically by slit lamp examination as Grade 1(Group 1), Grade 2(Group 2)and Grade 3(Group 3). For each subject,fasting sample of venous blood was collected to determine the serum total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), apolipoprotein A1(APOA1)and apolipoprotein B(APOB). The blood lipid levels of each group were compared and analyzed.

RESULTS: TC, LDL-C and APOB levels were significantly higher in the pterygium group than in the control group respectively(P=0.024, 0.012, 0.009). TG level was higher in pterygium group than control, but there was not significance(P>0.05). HDL-C and APOA1 levels were lower in pterygium group than control, but there were not significance too(P>0.05). Statistically significant differences were present for the LDL-C levels among pterygium groups graded clinically(2.76±0.57mmol/L, 3.40±0.96mmol/L and 3.85±1.16mmol/L, P=0.036), but were not present all for TC, TG, HDL-C, APOA1 and APOB levels(P>0.05). Comparing the groups, LDL-C values were significantly higher in group 3 than in Group 1(P=0.012).

CONCLUSION: Hyperlipidemia has close relationship with bilateral primary pterygium and may be one of its risk factors.