目的：探究蠕形螨感染对睑板腺功能障碍(MGD)患者眼表功能的影响作用。

方法：选取2018-04/09南方医科大学附属珠江医院眼科门诊MGD患者94例94眼，入组患者检查以下指标：眼表疾病指数(OSDI)、Schirmer I试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光染色(FL)、泪河高度、上睑板腺缺失评分、下睑板腺缺失评分、睑板腺缺失总评分、蠕形螨计数，对比蠕形螨检出阳性组和阴性组以上指标有无差异并分析蠕形螨检出阳性组蠕形螨计数与以上指标相关性。

结果： MGD患者94眼中54眼蠕形螨阳性，检出阳性率57%，与年龄无明显相关，男性中检出率高于女性。蠕形螨检出阳性组上睑板腺缺失评分及睑板腺缺失总评分高于蠕形螨检出阴性组\〖2.00(1.00， 2.00)vs 1.00(1.00， 1.50)分，P=0.02； 3.00(2.00， 4.00)vs 2.00(1.00， 3.00)分，P=0.04\〗，OSDI、S I t、BUT、FL、下睑板腺缺失评分无差异(P>0.05)。蠕形螨检出阳性的MGD患者中蠕形螨计数与上睑板腺缺失分级评分(r_s=0.37，P=0.03)、睑板腺缺失总评分(r_s=0.44，P=0.01)呈正相关，与其他检查指标无明显相关性。

结论：蠕形螨在睑板腺功能障碍患者眼表功能有一定影响作用，与睑板腺缺失呈正相关，蠕形螨感染数量增加，睑板腺缺失加重，进而加重眼部不适症状。

METHODS: Totally 94 patients with MGD were enrolled in the Ophthalmology Clinic of Zhujiang Hospital of Southern Medical University from April 2018 to September 2018. The patients were conducted a series of tests for Ocular Surface Disease Index(OSDI), Schirmer I test(SⅠt), tear film break-up time(BUT), corneal fluorescence staining(FL), tear height, superior meibomian gland loss score, inferior meibomian gland loss score, total meibomian gland loss score, and demodex count. The difference between above indicators in the positive group and in the negative group was calculated, and the correlation between demodex count and above ocular surface parameters was analyzed.

RESULTS: All 54 patients were tested positive for Demodex, and the positive rate was 57%, which was not significantly correlated with age. The positive rate of Demodex in males was higher than that in females. The superior meibomian gland loss scoreandtotalmeibomian gland loss score \〖2.00(1.00, 2.00)vs 1.00(1.00, 1.50),P=0.02; 3.00(2.00, 4.00)vs 2.00(1.00, 3.00),P=0.04\〗in positive group were significant higher than that in negative group. There were no significant differences in OSDI, S I t, BUT, FL, and inferior meibomian gland loss score between two groups(all P>0.05). Demodex count showed mild to moderate correlations with superior meibomian gland loss score(r_s=0.37, P=0.03)and total meibomian gland loss score(r_s=0.44, P=0.01)in Demodex-positive group. While there were no significant correlation between demodex count and other parameters.

CONCLUSION: Demodex mites have a certain effect on the ocular surface functions of MGD patients and it was positive correlate with the loss of meibomian glands.