目的：评估FS-LASIK联合快速角膜胶原交联术治疗高度近视的疗效。

方法：前瞻性自身对照研究。选取2017-06/09在我院行FS-LASIK联合快速角膜胶原交联术治疗的高度近视患者42例81眼，术后随访6mo，观察患者的裸眼视力(UCVA)、等效球镜度(SE)、角膜形态参数、矫正眼压及手术并发症情况。

结果：术后6mo，本组患者UCVA(LogMAR)从术前1.44±0.18提高到-0.03±0.04，SE从-8.01±1.23D减少到-0.06±0.54D，角膜最陡峭曲率由44.23±0.80D下降到37.39±1.17D，角膜最平坦曲率由42.87±0.61D下降到36.84±0.99D，角膜最薄点厚度由525.33±30.42μm下降到402.12±28.04μm，矫正眼压由17.77±2.16mmHg下降至16.69±0.41mmHg，而角膜最薄点后表面高度和内皮细胞密度无显著变化。术后随访未见角膜感染、严重的非感染性炎症及角膜瓣相关并发症。

结论：FS-LASIK联合快速角膜胶原交联术治疗高度近视安全、有效，术后角膜形态和屈光度相对稳定。

METHODS: A prospective self-control study. Totally 42 patients(81 eyes)with high myopia treated by FS-LASIK combined with rapid corneal collagen cross-linking in our hospital from June to September 2017 were followed up for 6mo. The uncorrected visual acuity(UCVA), spherical equivalent(SE), corneal morphological parameters, corrected intraocular pressure and complications were observed.

RESULTS: At 6mo after operation, the UCVA(LogMAR)increased from 1.44±0.18 before operation to -0.03±0.04, the SE degree reduced from -8.01±1.23D to -0.06±0.54D, the steepest corneal curvature(Steep K)decreased from 44.23±0.80D to 37.39±1.17D at 6mo after operation, the flattest corneal curvature(Fleep K)decreased from 42.87±0.61D before operation to 36.84±0.99D after operation. And the thinnest point thickness of cornea decreased from 525.33±30.42μm to 402.12±28.04μm, the corrected intraocular pressure decreased from 17.77±2.16mmHg to 16.69±0.41mmHg. There were no significant changes in the posterior surface height of thinnest cornea and the endothelial cell density. No corneal infections, serious non-infectious inflammation and complications related to corneal flaps were found during follow-up.

CONCLUSION: FS-LASIK combined with rapid corneal collagen cross-linking is safe and effective in treatment of high myopia. The corneal morphology and refraction are relatively stable after surgery.