抗VEGF联合激光治疗视网膜静脉阻塞合并黄斑水肿

Anti-VEGF combined with retinal laser in treatment of retinal vein occlusion with macular edema

摘要:

目的：观察抗VEGF联合激光治疗视网膜静脉阻塞合并黄斑水肿的临床疗效。

方法：选取2017-03/09在我院眼科确诊的视网膜静脉阻塞合并黄斑水肿患者62例62眼，随机进行分组，A组行单纯视网膜激光治疗，B组和C组先分别行玻璃体腔注射康柏西普和雷珠单抗，再进行视网膜激光治疗。随访6mo，观察三组患者的临床疗效。

结果：治疗后三组患者黄斑中心视网膜厚度(CMT)均较治疗前显著降低，且B组和C组患者CMT均低于A组(P<0.05)，但两组之间无差异(P>0.05)。治疗后6mo，三组患者治疗总有效率分别为44%、86%、86%(P<0.05)，B组和C组患者治疗总有效率均高于A组(P<0.0167)。

结论：玻璃体腔注射康柏西普或雷珠单抗联合视网膜激光治疗视网膜静脉阻塞合并黄斑水肿可有效减轻黄斑水肿，改善视力，疗效相似。

Abstract:

AIM: To observe the clinical efficacy of anti-VEGF combined with laser in treatment of retinal vein occlusion with macular edema.

METHODS: Totally 62 patients with retinal vein occlusion complicated with macular edema were diagnosed in the Ophthalmology Department of our hospital during 2017-03/09 were randomly divided into three groups. Group A was treated by retinal laser alone, and groups B and C were treated with intravitreal injection of conbercept and rezuzumab respectively before retinal laser a follow-up of 6mo was conducted to observe the clinical efficacy of three groups.

RESULTS: After treatment, the retinal thickness(CMT)in macular center of the three groups was significantly lower than that before treatment, and the CMT of groups B and C were lower than that of group A(P<0.05), but there was no difference between the two groups(P>0.05). At 6mo after treatment, the total effective rate of the three groups was 44%, 86% and 86%, respectively(P<0.05), and the total effective rate of groups B and C was higher than that of group A(P<0.0167).

CONCLUSION: Vitreous injection of conbercept or ranibizumab combined with retinal laser in treatment of retinal vein occlusion with macular edema can effectively reduce macular edema and improve vision. Conbercept or ranibizumab has similar effects.