芪三酚对糖尿病白内障模型大鼠体质量和生化指标的影响

Effect of resvertrol on body mass and biochemical indexes of diabetic cataract model rats

摘要:

目的：研究芪三酚对糖尿病白内障模型大鼠体质量和生化指标的影响。

方法：将30只大鼠分为空白组、模型组、治疗组各10只。空白组大鼠不做处理，模型组、治疗组大鼠进行建模，使用芪三酚对治疗组大鼠进行干预，并对各组大鼠晶状体混浊情况、体质量、身长及生化指标水平进行检测，对三组大鼠右眼眼球进行HE染色。

结果：空白组大鼠晶状体透明，无混浊现象； 治疗组大鼠晶状体混浊程度和白内障整体评分均优于模型组(P<0.05)； 第3、5wk时，治疗组大鼠体质量、身长高于模型组，空腹血糖(FPG)和餐后2h血糖(2hPG)水平低于模型组(P<0.05)； 5wk后，相比模型组大鼠，治疗组各项生化指标水平均明显改善(P<0.05)。

结论：芪三酚能够改善糖尿病白内障大鼠晶状体混浊程度，减轻疾病对大鼠体质量的影响，调控大鼠血糖、生化指标水平，缓解白内障进展。

Abstract:

AIM: To study the effect of resveratrol on body mass and biochemical parameters of diabetic cataract model rats.

METHODS: Thirty rats were divided into blank group, model group and treatment group with 10 rats for each. Rats in the blank group were not treated. Rats in the model group and the treatment group were modeled. Rats in the treatment group were intervened with astragalol. Lens opacity, body mass, body growth and biochemical indexes of rats in each group were detected. The right eyeballs of rats in the three groups were stained with HE.

RESULTS: The rats in the blank group had transparent lens and no opacity; the degree of lens opacity and the overall score of cataract in the treatment group were better than those in the model group(P<0.05); at 3^rd and 5^th weeks, the body weight and length of the rats in the treatment group were higher than those in the model group, and the levels of FPG and 2hPG were lower than those in the model group(P<0.05); after 5wk, the biochemical indexes in the treatment group were significantly improved compared with those in the model group(P<0.05).

CONCLUSION: Astragall can improve the degree of lens opacity in diabetic cataract rats, alleviate the effect of disease on the body weight of rats, regulate the level of blood sugar and biochemical indicators in rats, and alleviate the progress of cataract.