中性粒细胞及血小板与淋巴细胞比值与2型糖尿病视网膜病变相关性

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and type 2 diabetic retinopathy

摘要:

目的：探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。

方法：选择2型糖尿病(DM)患者200例， 按眼底检查结果分为眼底正常组(n=100)、非增殖期视网膜病变组(NPDR， n=62)和增殖期视网膜病变组(PDR， n=38)。同时选取100例健康体检者作为正常对照(n=100)组； 测定中性粒细胞、淋巴细胞及血小板计数等相关指标。

结果： PDR组患者NLR值(2.54)高于对照组(1.81)、DM组(1.76)及NPDR组(1.85)，差异有统计学意义(P<0.05)，PDR组患者PLR值(126.18)高于DM组(111.64)，差异有统计学意义(P<0.05)。Logistic回归分析显示，年龄(β=-0.047)是糖尿病视网膜病变的保护因素(P<0.05)，病程(β=0.071)和收缩压(β=0.024)是危险因素(P<0.05)，而NLR、PLR在回归分析中无统计学意义。

结论：NLR、PLR值在PDR组升高，但并非糖尿病视网膜病变发生的独立危险因素。

Abstract:

AIM: To investigate the relationship between neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR)and type 2 diabetic retinopathy(DR).

METHODS:A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus(DM, n=100), non-proliferative diabetic retinopathy(NPDR, n=62)and proliferative diabetic retinopathy(PDR, n=38). 100 healthy persons were selected as the normal control group(NCG, n=100). The related indicators, such as neutrophil count, lymphocyte count and platelet count were measured.

RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group(1.81), DM group(1.76)and NPDR group(1.85)(P<0.05). The value of PLR was significantly higher in PDR group patients(126.18)than in DM group(111.64)(P<0.05). Logistic regression analysis showed that age(β= -0.047)was protective factor, course of diabetes(β=0.071)and systolic blood pressure(β=0.024)were risk factors for diabetic retinopathy(P<0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis.

CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.